2019

  1. Osman, S. O. S., Leijenaar, R. T. H., Cole, A. J., Lyons, C. A., Hounsell, A. R., Prise, K. M., … Jain, S. (2019). Computed Tomography-based Radiomics for Risk Stratification in Prostate Cancer. International Journal of Radiation Oncology Biology Physics, 105(2), 448-456. https://doi.org/10.1016/j.ijrobp.2019.06.2504
  2. Ibrahim, A., Vallieres, M., Woodruff, H., Primakov, S., Beheshti, M., Keek, S., … Mottaghy, F. M. (2019). Radiomics Analysis for Clinical Decision Support in Nuclear Medicine. Seminars in Nuclear Medicine, 49(5), 438-449. https://doi.org/10.1053/j.semnuclmed.2019.06.005
  3. Peerlings, J., Paulis, L., Mitea, C., Bakers, F., Berbee, M., Wierts, R., … Mottaghy, F. (2019). Performing clinical F-18-FDG-PET/MRI of the mediastinum optimising a dedicated, patient-friendly protocol. Nuclear Medicine Communications, 40(8), 815-826. https://doi.org/10.1097/MNM.0000000000001035
  4. Ankolekar, A., Vanneste, B. G. L., Bloemen-van Gurp, E., van Roermund, J. G., van Limbergen, E. J., van de Beek, K., … Fijten, R. (2019). Development and validation of a patient decision aid for prostate Cancer therapy: from paternalistic towards participative shared decision making. BMC Medical Informatics and Decision Making, 19, [130]. https://doi.org/10.1186/s12911-019-0862-4
  5. van Timmeren, J. E., van Elmpt, W., Leijenaar, R. T. H., Reymen, B., Monshouwer, R., Bussink, J., … Lambin, P. (2019). Longitudinal radiomics of cone-beam CT images from non-small cell lung cancer patients: Evaluation of the added prognostic value for overall survival and locoregional recurrence. Radiotherapy and Oncology, 136, 78-85. https://doi.org/10.1016/j.radonc.2019.03.032
  6. van Timmeren, J. E., Carvalho, S., Leijenaar, R. T. H., Troost, E. G. C., van Elmpt, W., de Ruysscher, D., … Lambin, P. (2019). Challenges and caveats of a multi-center retrospective radiomics study: an example of early treatment response assessment for NSCLC patients using FDG-PET/CT radiomics. PLOS ONE, 14(6), [0217536]. https://doi.org/10.1371/journal.pone.0217536
  7. IBCD Fac (2019). Addressing the dichotomy between individual and societal approaches to personalised medicine in oncology. European Journal of Cancer, 114, 128-136. https://doi.org/10.1016/j.ejca.2019.03.025
  8. Lindblom, E. K., Ureba, A., Dasu, A., Wersall, P., Even, A. J. G., van Elmpt, W., … Toma-Dasu, I. (2019). Impact of SBRT fractionation in hypoxia dose painting – Accounting for heterogeneous and dynamic tumor oxygenation. Medical Physics, 46(5), 2512-2521. https://doi.org/10.1002/mp.13514
  9. Ankolekar, A., Vanneste, B., Bloemen, E., Van Roermund, J., Van Limbergen, E., Van de Beek, K., … Berlanga, A. (2019). Development and Validation of a Prostate Cancer Patient Decision Aid: Towards Participative Medicine. Radiotherapy and Oncology, 133, S450-S451. https://doi.org/10.1016/S0167-8140(19)31275-7
  10. Peerlings, J., Woodruff, H. C., Winfield, J. M., Ibrahim, A., Van Beers, B. E., Heerschap, A., … Lambin, P. (2019). Stability of radiomics features in apparent diffusion coefficient maps from a multi-centre test-retest trial. Scientific Reports, 9, 1-10. [4800]. https://doi.org/10.1038/s41598-019-41344-5
  11. Walsh, S., de Jong, E. E. C., van Timmeren, J. E., Ibrahim, A., Compter, I., Peerlings, J., … Lambin, P. (2019). Decision Support Systems in Oncology. JCO Clinical Cancer Informatics, 3, 1-9. https://doi.org/10.1200/CCI.18.00001
  12. Spiegelberg, L., Houben, R., Niemans, R., de Ruysscher, D., Yaromina, A., Theys, J., … Dubois, L. J. (2019). Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials. Clinical and Translational Radiation Oncology, 15, 62-69. https://doi.org/10.1016/j.ctro.2019.01.005
  13. Deist, T. M., Dankers, F. J. W. M., Valdes, G., Wijsman, R., Hsu, I-C., Oberije, C., … Lambin, P. (2019). Machine learning algorithms for outcome prediction in (chemo) radiotherapy: An empirical comparison of classifiers (vol 45, pg 3449, 2018). Medical Physics, 46(2), 1080-1087. https://doi.org/10.1002/mp.13329
  14. Vanneste, B. G. L., Buettner, F., Pinkawa, M., Lambin, P., & Hoffmann, A. L. (2019). Ano-rectal wall dose-surface maps localize the dosimetric benefit of hydrogel rectum spacers in prostate cancer radiotherapy. Clinical and Translational Radiation Oncology, 14, 17-24. https://doi.org/10.1016/j.ctro.2018.10.006
  15. Rizzo, S., Raimondi, S., de Jong, E. E. C., van Elmpt, W., De Piano, F., Petrella, F., … Lambin, P. (2019). Genomics of non-small cell lung cancer (NSCLC): Association between CT-based imaging features and EGFR and K-RAS mutations in 122 patients-An external validation. European Journal of Radiology, 110, 148-155. https://doi.org/10.1016/j.ejrad.2018.11.032
  16. Eekers, D. B. P., Roelofs, E., Cubillos-Mesias, M., Niel, C., Smeenk, R. J., Hoeben, A., … Troost, E. G. C. (2019). Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients: results of a multicentric in silico ROCOCO trial. Acta Oncologica, 58(1), 57-65. https://doi.org/10.1080/0284186X.2018.1529424
  17. Meaney, C., Powathil, G. G., Yaromina, A., Dubois, L. J., Lambin, P., & Kohandel, M. (2019). Role of hypoxia-activated prodrugs in combination with radiation therapy: An in silico approach. Mathematical Biosciences and Engineering, 16(6), 6257-6273. https://doi.org/10.3934/mbe.2019312
  18. 2018
  19. Morin, O., Vallieres, M., Jochems, A., Woodruff, H. C., Valdes, G., Braunstein, S. E., … Lambin, P. (2018). A Deep Look Into the Future of Quantitative Imaging in Oncology: A Statement of Working Principles and Proposal for Change. International Journal of Radiation Oncology Biology Physics, 102(4), 1074-1082. https://doi.org/10.1016/j.ijrobp.2018.08.032
  20. Klaassen, R., Larue, R. T. H. M., Mearadji, B., van der Woude, S. O., Stoker, J., Lambin, P., & van Laarhoven, H. W. M. (2018). Feasibility of CT radiomics to predict treatment response of individual liver metastases in esophagogastric cancer patients. PLOS ONE, 13(11), [0207362]. https://doi.org/10.1371/journal.pone.0207362
  21. Dinapoli, N., Barbaro, B., Gatta, R., Chiloiro, G., Casa, C., Masciocchi, C., … Valentini, V. (2018). Magnetic Resonance, Vendor-independent, Intensity Histogram Analysis Predicting Pathologic Complete Response After Radiochemotherapy of Rectal Cancer. International Journal of Radiation Oncology Biology Physics, 102(4), 765-774. https://doi.org/10.1016/j.ijrobp.2018.04.065
  22. Press, R. H., Shu, H-K. G., Shim, H., Mountz, J. M., Kurland, B. F., Wahl, R. L., … Buatti, J. M. (2018). The Use of Quantitative Imaging in Radiation Oncology: A Quantitative Imaging Network (QIN) Perspective. International Journal of Radiation Oncology Biology Physics, 102(4), 1219-1235. https://doi.org/10.1016/j.ijrobp.2018.06.023
  23. Haider, S., Yao, C. Q., Sabine, V. S., Grzadkowski, M., Stimper, V., Starmans, M. H. W., … Boutros, P. C. (2018). Pathway-based subnetworks enable cross-disease biomarker discovery. Nature Communications, 9, [4746]. https://doi.org/10.1038/s41467-018-07021-3
  24. van Wijk, Y., Vanneste, B. G. L., Jochems, A., Walsh, S., Oberije, C. J., Pinkawa, M., … Lambin, P. (2018). Development of an isotoxic decision support system integrating genetic markers of toxicity for the implantation of a rectum spacer. Acta Oncologica, 57(11), 1499-1505. https://doi.org/10.1080/0284186X.2018.1484156
  25. Larue, R. T. H. M., Klaassen, R., Jochems, A., Leijenaar, R. T. H., Hulshof, M. C. C. M., Henegouwen, M. I. V. B., … Lambin, P. (2018). Pre-treatment CT radiomics to predict 3-year overall survival following chemoradiotherapy of esophageal cancer. Acta Oncologica, 57(11), 1475-1481. https://doi.org/10.1080/0284186X.2018.1486039
  26. de Jong, E. E. C., van Elmpt, W., Rizzo, S., Colarieti, A., Spitaleri, G., Leijenaar, R. T. H., … Lambin, P. (2018). Applicability of a prognostic CT-based radiomic signature model trained on stage I-III non-small cell lung cancer in stage IV non-small cell lung cancer. Lung Cancer, 124, 6-11. https://doi.org/10.1016/j.lungcan.2018.07.023
  27. Deist, T. M., Dankers, F. J. W. M., Valdes, G., Wijsman, R., Hsu, I-C., Oberije, C., … Lambin, P. (2018). Machine learning algorithms for outcome prediction in (chemo)radiotherapy: An empirical comparison of classifiers. Medical Physics, 45(7), 3449-3459. https://doi.org/10.1002/mp.12967
  28. Aspatwar, A., Becker, H. M., Parvathaneni, N. K., Hammaren, M., Svorjova, A., Barker, H., … Winum, J-Y. (2018). Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes. Journal of Enzyme Inhibition and Medicinal Chemistry, 33(1), 1064-1073. https://doi.org/10.1080/14756366.2018.1482285
  29. Jaffray, D. A., Das, S., Jacobs, P. M., Jeraj, R., & Lambin, P. (2018). How Advances in Imaging Will Affect Precision Radiation Oncology. International Journal of Radiation Oncology Biology Physics, 101(2), 292-298. https://doi.org/10.1016/j.ijrobp.2018.01.047
  30. Zindler, J. D., Schiffelers, J., Lambin, P., & Hoffmann, A. L. (2018). Improved effectiveness of stereotactic radiosurgery in large brain metastases by individualized isotoxic dose prescription: an in silico study. Strahlentherapie Und onkologie, 194(6), 560-569. https://doi.org/10.1007/s00066-018-1262-x
  31. Sanduleanu, S., Woodruff, H. C., de Jong, E. E. C., van Timmeren, J. E., Jochems, A., Dubois, L., & Lambin, P. (2018). Tracking tumor biology with radiomics: A systematic review utilizing a radiomics quality score. Radiotherapy and Oncology, 127(3), 349-360. https://doi.org/10.1016/j.radonc.2018.03.033
  32. Hartgerink, D., van der Heijden, B., De Ruysscher, D., Postma, A., Ackermans, L., Hoeben, A., … Zindler, J. (2018). Stereotactic Radiosurgery in the Management of Patients With Brain Metastases of Non-Small Cell Lung Cancer: Indications, Decision Tools and Future Directions. Frontiers in Oncology, 8, [154]. https://doi.org/10.3389/fonc.2018.00154
  33. Melnikov, A. V., Shuba, M., & Lambin, P. (2018). Modeling the electrical properties of three-dimensional printed meshes with the theory of resistor lattices. Physical Review E, 97(4), [043307]. https://doi.org/10.1103/PhysRevE.97.043307
  34. Cusumano, D., Dinapoli, N., Boldrini, L., Chiloiro, G., Gatta, R., Masciocchi, C., … Valentini, V. (2018). Fractal-based radiomic approach to predict complete pathological response after chemo-radiotherapy in rectal cancer. Radiologia medica, 123(4), 286-295. https://doi.org/10.1007/s11547-017-0838-3
  35. Apeke, S., Gaubert, L., Boussion, N., Lambin, P., Visvikis, D., Rodin, V., & Redou, P. (2018). Multi-Scale Modeling and Oxygen Impact on Tumor Temporal Evolution: Application on Rectal Cancer During Radiotherapy. Ieee Transactions on Medical Imaging, 37(4), 871-880. https://doi.org/10.1109/TMI.2017.2771379
  36. Carvalho, S., Leijenaar, R. T. H., Troost, E. G. C., van Timmeren, J. E., Oberije, C., van Elmpt, W., … Lambin, P. (2018). F-18-fluorodeoxyglucose positron-emission tomography (FDG-PET)-Radiomics of metastatic lymph nodes and primary tumor in non-small cell lung cancer (NSCLC): A prospective externally validated study. PLOS ONE, 13(3), [e0192859]. https://doi.org/10.1371/journal.pone.0192859
  37. Lazzeroni, M., Uhrdin, J., Carvalho, S., van Elmpt, W., Lambin, P., Dasu, A., … Toma-Dasu, I. (2018). Evaluation of third treatment week as temporal window for assessing responsiveness on repeated FDG-PET-CT scans in Non-Small Cell Lung Cancer patients. Physica Medica: European journal of medical physics, 46, 45-51. https://doi.org/10.1016/j.ejmp.2018.01.012
  38. Eekers, D. B. P., Pijnappel, E. N., Schijns, O. E. M. G., Colon, A., Hoeben, A., Zindler, J. D., … Troost, E. G. C. (2018). Evidence on the efficacy of primary radiosurgery or stereotactic radiotherapy for drug-resistant non-neoplastic focal epilepsy in adults: A systematic review. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 55, 83-92. https://doi.org/10.1016/j.seizure.2018.01.009
  39. Walsh, S., Roelofs, E., Kuess, P., van Wijk, Y., Vanneste, B., Dekker, A., … Verhaegen, F. (2018). Towards a Clinical Decision Support System for External Beam Radiation Oncology Prostate Cancer Patients: Proton vs. Photon Radiotherapy? A Radiobiological Study of Robustness and Stability. Cancers, 10(2), [55]. https://doi.org/10.3390/cancers10020055
  40. Jochems, A., El-Naqa, I., Kessler, M., Mayo, C. S., Jolly, S., Matuszak, M., … Lambin, P. (2018). A prediction model for early death in non-small cell lung cancer patients following curative-intent chemoradiotherapy. Acta Oncologica, 57(2), 226-230. https://doi.org/10.1080/0284186X.2017.1385842
  41. Leijenaar, R. T. H., Bogowicz, M., Jochems, A., Hoebers, F. J. P., Wesseling, F. W. R., Huang, S. H., … Lambin, P. (2018). Development and validation of a radiomic signature to predict HPV (p16) status from standard CT imaging: a multicenter study. British Journal of Radiology, 91(1086), [2017049811075]. https://doi.org/10.1259/bjr.20170498
  42. Vanneste, B. G. L., van Wijk, Y., Lutgens, L. C., Van Limbergen, E. J., van Lin, E. N., van de Beek, K., … Hoffmann, A. L. (2018). Dynamics of rectal balloon implant shrinkage in prostate VMAT: Influence on anorectal dose and late rectal complication risk. Strahlentherapie Und onkologie, 194(1), 31-40. https://doi.org/10.1007/s00066-017-1222-x
  43. Ureba, A., Lindblom, E., Dasu, A., Uhrdin, J., Even, A. J. G., van Elmpt, W., … Toma-Dasu, I. (2018). Non-linear conversion of HX4 uptake for automatic segmentation of hypoxic volumes and dose prescription. Acta Oncologica, 57(4), 485-490. https://doi.org/10.1080/0284186X.2017.1400177
  44. Salem, A., Asselin, M-C., Reymen, B., Jackson, A., Lambin, P., West, C. M. L., … Faivre-Finn, C. (2018). Targeting Hypoxia to Improve Non-Small Cell Lung Cancer Outcome. Journal of the National Cancer Institute, 110(1), 14-30. https://doi.org/10.1093/jnci/djx160
  45. Rekers, N. H., Pimentel, V. O., Yaromina, A., Lieuwes, N. G., Biemans, R., Zegers, C. M. L., … Lambin, P. (2018). The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses. OncoImmunology , 7(4), [e1414119]. https://doi.org/10.1080/2162402X.2017.1414119
  46. Eekers, D. B. P., Ven, L. I., Deprez, S., Jacobi, L., Roelofs, E., Hoeben, A., … Troost, E. G. C. (2018). The posterior cerebellum, a new organ at risk? Clinical and Translational Radiation Oncology, 8, 22-26. https://doi.org/10.1016/j.ctro.2017.11.010
  47. Kazokaite, J., Niemans, R., Dudutiene, V., Becker, H. M., Leitans, J., Zubriene, A., … Matulis, D. (2018). Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells. Oncotarget, 9(42), 26800-26816. https://doi.org/10.18632/oncotarget.25508
  48. Baum, R. P., Kulkarni, H. R., Singh, A., Kaemmerer, D., Mueller, D., Prasad, V., … Horsch, D. (2018). Results and adverse events of personalized peptide receptor radionuclide therapy with 90Yttrium and 177Lutetium in 1048 patients with neuroendocrine neoplasms. Oncotarget, 9(24), 16932-16950. https://doi.org/10.18632/oncotarget.24524
  49. 2017
  50. Even, A. J. G., Reymen, B., La Fontaine, M. D., Das, M., Mottaghy, F. M., Belderbos, J. S. A., … van Elmpt, W. (2017). Clustering of multi-parametric functional imaging to identify high-risk subvolumes in non-small cell lung cancer. Radiotherapy and Oncology, 125(3), 379-384. https://doi.org/10.1016/j.radonc.2017.09.041
  51. Bogowicz, M., Leijenaar, R. T. H., Tanadini-Lang, S., Riesterer, O., Pruschy, M., Studer, G., … Lambin, P. (2017). Post-radiochemotherapy PET radiomics in head and neck cancer – The influence of radiomics implementation on the reproducibility of local control tumor models. Radiotherapy and Oncology, 125(3), 385-391. https://doi.org/10.1016/j.radonc.2017.10.023
  52. Lambin, P., Leijenaar, R. T. H., Deist, T. M., Peerlings, J., de Jong, E. E. C., van Timmeren, J., … Walsh, S. (2017). Radiomics: the bridge between medical imaging and personalized medicine. Nature Reviews Clinical Oncology, 14(12), 749-762. https://doi.org/10.1038/nrclinonc.2017.141
  53. Tunali, I., Stringfield, O., Guvenis, A., Wang, H., Liu, Y., Balagurunathan, Y., … Schabath, M. B. (2017). Radial gradient and radial deviation radiomic features from pre-surgical CT scans are associated with survival among lung adenocarcinoma patients. Oncotarget, 8(56), 96013-96026. https://doi.org/10.18632/oncotarget.21629
  54. Peerlings, J., Van De Voorde, L., Mitea, C., Larue, R., Yaromina, A., Sandeleanu, S., … Mottaghy, F. M. (2017). Hypoxia and hypoxia response-associated molecular markers in esophageal cancer: A systematic review. Methods, 130, 51-62. https://doi.org/10.1016/j.ymeth.2017.07.002
  55. Hanzouli-Ben Salah, H., Lapuyade-Lahorgue, J., Bert, J., Benoit, D., Lambin, P., Van Baardwijk, A., … Hatt, M. (2017). A framework based on hidden Markov trees for multimodal PET/CT image co-segmentation. Medical Physics, 44(11), 5835-5848. https://doi.org/10.1002/mp.12531
  56. Jochems, A., Deist, T. M., El Naqa, I., Kessler, M., Mayo, C., Reeves, J., … Dekker, A. (2017). Developing and Validating a Survival Prediction Model for NSCLC Patients Through Distributed Learning Across 3 Countries. International Journal of Radiation Oncology Biology Physics, 99(2), 344-352. https://doi.org/10.1016/j.ijrobp.2017.04.021
  57. Larue, R. T. H. M., Van De Voorde, L., van Timmeren, J. E., Leijenaar, R. T. H., Berbee, M., Sosef, M. N., … Lambin, P. (2017). 4DCT imaging to assess radiomics feature stability: An investigation for thoracic cancers. Radiotherapy and Oncology, 125(1), 147-153. https://doi.org/10.1016/j.radonc.2017.07.023
  58. van Wijk, Y., Vanneste, B. G. L., Walsh, S., van der Meer, S., Ramaekers, B., van Elmpt, W., … Lambin, P. (2017). Development of a virtual spacer to support the decision for the placement of an implantable rectum spacer for prostate cancer radiotherapy: Comparison of dose, toxicity and cost-effectiveness. Radiotherapy and Oncology, 125(1), 107-112. https://doi.org/10.1016/j.radonc.2017.07.026
  59. Alitto, A. R., Gatta, R., Vanneste, B. G. L., Vallati, M., Meldolesi, E., Damiani, A., … Mantini, G. (2017). PRODIGE: PRediction models in prOstate cancer for personalized meDIcine challenGE. Future Oncology, 13(24), 2171-2181. https://doi.org/10.2217/fon-2017-0142
  60. Yaromina, A., Granzier, M., Biemans, R., Lieuwes, N., van Elmpt, W., Shakirin, G., … Lambin, P. (2017). A novel concept for tumour targeting with radiation: Inverse dose-painting or targeting the “Low Drug Uptake Volume”. Radiotherapy and Oncology, 124(3), 513-520. https://doi.org/10.1016/j.radonc.2017.04.020
  61. van Gisbergen, M. W., Voets, A. M., Biemans, R., Hoffmann, R. F., Drittij-Reijnders, M-J., Haenen, G. R. M. M., … Lambin, P. (2017). Distinct radiation responses after in vitro mtDNA depletion are potentially related to oxidative stress. PLOS ONE, 12(8), [0182508]. https://doi.org/10.1371/journal.pone.0182508
  62. Velazquez, E. R., Hoebers, F., Aerts, H. J. W. L., Rietbergen, M. M., Brakenhoff, R. H., Leemans, R. C., … Lambin, P. (2017). Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than TNM staging (vol 113, pg 324, 2014). Radiotherapy and Oncology, 124(2), 337-338. https://doi.org/10.1016/j.radonc.2017.06.017
  63. Ou, D., Blanchard, P., Rosellini, S., Levy, A., Nguyen, F., Leijenaar, R. T. H., … Tao, Y. (2017). Predictive and prognostic value of CT based radiomics signature in locally advanced head and neck cancers patients treated with concurrent chemoradiotherapy or bioradiotherapy and its added value to Human Papillomavirus status. Oral Oncology, 71, 150-155. https://doi.org/10.1016/j.oraloncology.2017.06.015
  64. Zindler, J. D., Bruynzeel, A. M. E., Eekers, D. B. P., Hurkmans, C. W., Swinnen, A., & Lambin, P. (2017). Whole brain radiotherapy versus stereotactic radiosurgery for 4-10 brain metastases: a phase III randomised multicentre trial. BMC Cancer, 17, [500]. https://doi.org/10.1186/s12885-017-3494-z
  65. Grossmann, P., Stringfield, O., El-Hachem, N., Bui, M. M., Velazquez, E. R., Parmar, C., … Aerts, H. J. W. L. (2017). Defining the biological basis of radiomic phenotypes in lung cancer. Elife, 6, [23421]. https://doi.org/10.7554/eLife.23421
  66. Deist, T., Jochems, A., van Soest, J., Nalbantov, G., Oberije, C., Walsh, S., … Lambin, P. (2017). Infrastructure and distributed learning methodology for privacy-preserving multi-centric rapid learning health care: euroCAT. Clinical and Translational Radiation Oncology, 4, 24-31. https://doi.org/10.1016/j.ctro.2016.12.004
  67. van Timmeren, J. E., Leijenaar, R. T. H., van Elmpt, W., Reymen, B., Oberije, C., Monshouwer, R., … Lambin, P. (2017). Survival prediction of non-small cell lung cancer patients using radiomics analyses of cone-beam CT images. Radiotherapy and Oncology, 123(3), 363-369. https://doi.org/10.1016/j.radonc.2017.04.016
  68. Zindler, J. D., Jochems, A., Lagerwaard, F. J., Beumer, R., Troost, E. G. C., Eekers, D. B. P., … Lambin, P. (2017). Individualized early death and long-term survival prediction after stereotactic radiosurgery for brain metastases of non-small cell lung cancer: Two externally validated nomograms. Radiotherapy and Oncology, 123(2), 189-194. https://doi.org/10.1016/j.radonc.2017.02.006
  69. Azria, D., Lapierre, A., Gourgou, S., De Ruysscher, D., Colinge, J., Lambin, P., … Rosenstein, B. S. (2017). Data-Based Radiation Oncology: Design of Clinical Trials in the Toxicity Biomarkers Era. Frontiers in Oncology, 7, [83]. https://doi.org/10.3389/fonc.2017.00083
  70. O’Connor, J. P. B., Aboagye, E. O., Adams, J. E., Aerts, H. J. W. L., Barrington, S. F., Beer, A. J., … Waterton, J. C. (2017). Imaging biomarker roadmap for cancer studies. Nature Reviews Clinical Oncology, 14(3), 169-186. https://doi.org/10.1038/nrclinonc.2016.162
  71. van Kuijk, S. J. A., Parvathaneni, N. K., Niemans, R., van Gisbergen, M. W., Carta, F., Vullo, D., … Lambin, P. (2017). New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs. European Journal of Medicinal Chemistry, 127, 691-702. https://doi.org/10.1016/j.ejmech.2016.10.037
  72. van Loon, J., Even, A. J. G., Aerts, H. J. W. L., Ollers, M., Hoebers, F., van Elmpt, W., … Lambin, P. (2017). PET imaging of zirconium-89 labelled cetuximab: A phase I trial in patients with head and neck and lung cancer. Radiotherapy and Oncology, 122(2), 267-273. https://doi.org/10.1016/j.radonc.2016.11.020
  73. Even, A. J. G., Hamming-Vrieze, O., van Elmpt, W., Winnepenninckx, V. J. L., Heukelom, J., Tesselaar, M. E. T., … Lambin, P. (2017). Quantitative assessment of Zirconium-89 labeled cetuximab using PET/CT imaging in patients with advanced head and neck cancer: a theragnostic approach. Oncotarget, 8(3), 3870-3880. https://doi.org/10.18632/oncotarget.13910
  74. Lambin, P., Zindler, J., Vanneste, B. G. L., Van De Voorde, L., Eekers, D., Compter, I., … Walsh, S. (2017). Decision support systems for personalized and participative radiation oncology. Advanced Drug Delivery Reviews, 109, 131-153. https://doi.org/10.1016/j.addr.2016.01.006
  75. de Jong, E. E. C., van Elmpt, W., Leijenaar, R. T. H., Hoekstra, O. S., Groen, H. J. M., Smit, E. F., … Dingemans, A-M. C. (2017). [18F]FDG PET/CT-based response assessment of stage IV non-small cell lung cancer treated with paclitaxel-carboplatin-bevacizumab with or without nitroglycerin patches. European Journal of Nuclear Medicine and Molecular Imaging, 44(1), 8-16. https://doi.org/10.1007/s00259-016-3498-y
  76. Lustberg, T., van Soest, J., Jochems, A., Deist, T., van Wijk, Y., Walsh, S., … Dekker, A. (2017). Big Data in radiation therapy: challenges and opportunities. British Journal of Radiology, 90(1069), [20160689]. https://doi.org/10.1259/bjr.20160689
  77. Van Limbergen, E. J., De Ruysscher, D. K., Pimentel, V. O., Marcus, D., Berbee, M., Hoeben, A., … Lambin, P. (2017). Combining radiotherapy with immunotherapy: the past, the present and the future. British Journal of Radiology, 90(1076), [20170157]. https://doi.org/10.1259/bjr.20170157
  78. Lindblom, E., Dasu, A., Uhrdin, J., Even, A., van Elmpt, W., Lambin, P., … Toma-Dasu, I. (2017). Defining the hypoxic target volume based on positron emission tomography for image guided radiotherapy – the influence of the choice of the reference region and conversion function. Acta Oncologica, 56(6), 819-825. https://doi.org/10.1080/0284186X.2017.1293289
  79. van Timmeren, J. E., Leijenaar, R. T. H., van Elmpt, W., Reymen, B., & Lambin, P. (2017). Feature selection methodology for longitudinal cone-beam CT radiomics. Acta Oncologica, 56(11), 1537-1543. https://doi.org/10.1080/0284186X.2017.1350285
  80. Vanneste, B. G. L., van De Beek, K., Lutgens, L., & Lambin, P. (2017). Implantation of a biodegradable rectum balloon implant: Tips, Tricks and Pitfalls. International Braz J Urol, 43(6), 1033-1042. https://doi.org/10.1590/S1677-5538.IBJU.2016.0494
  81. Larue, R. T. H. M., van Timmeren, J. E., de Jong, E. E. C., Feliciani, G., Leijenaar, R. T. H., Schreurs, W. M. J., … Lambin, P. (2017). Influence of gray level discretization on radiomic feature stability for different CT scanners, tube currents and slice thicknesses: a comprehensive phantom study. Acta Oncologica, 56(11), 1544-1553. https://doi.org/10.1080/0284186X.2017.1351624
  82. Bongers, M. L., de Ruysscher, D., Oberije, C., Lambin, P., Uyl-de Groot, C. A., Belderbos, J., & Coupe, V. M. H. (2017). MODEL-BASED COST-EFFECTIVENESS OF CONVENTIONAL AND INNOVATIVE CHEMO-RADIATION IN LUNG CANCER. International Journal of Technology Assessment in Health Care, 33(6), 681-690. https://doi.org/10.1017/S0266462317000939
  83. Even, A. J. G., Reymen, B., La Fontaine, M. D., Das, M., Jochems, A., Mottaghy, F. M., … van Elmpt, W. (2017). Predicting tumor hypoxia in non-small cell lung cancer by combining CT, FDG PET and dynamic contrast-enhanced CT. Acta Oncologica, 56(11), 1591-1596. https://doi.org/10.1080/0284186X.2017.1349332
  84. van Soest, J., Meldolesi, E., van Stiphout, R., Gatta, R., Damiani, A., Valentini, V., … Dekker, A. (2017). Prospective validation of pathologic complete response models in rectal cancer: Transferability and reproducibility. Medical Physics, 44(9). https://doi.org/10.1002/mp.12423
  85. de Jong, E. E. C., van Elmpt, W., Hoekstra, O. S., Groen, H. J. M., Smit, E. F., Boellaard, R., … Dingemans, A-M. C. (2017). Quality assessment of positron emission tomography scans: recommendations for future multicentre trials. Acta Oncologica, 56(11), 1459-1464. https://doi.org/10.1080/0284186X.2017.1346824
  86. Larue, R. T. H. M., Defraene, G., De Ruysscher, D., Lambin, P., & Van Elmpt, W. (2017). Quantitative radiomics studies for tissue characterization: a review of technology and methodological procedures. British Journal of Radiology, 90(1070), [20160665]. https://doi.org/10.1259/bjr.20160665
  87. Jacobs, M., Boersma, L., Dekker, A., Swart, R., Lambin, P., de Ruysscher, D., … van Merode, F. (2017). What is the impact of innovation on output in healthcare with a special focus on treatment innovations in radiotherapy? A literature review. British Journal of Radiology, 90(1079), [20170251]. https://doi.org/10.1259/bjr.20170251
  88. 2016
  89. Verwer, E. E., Zegers, K., van Elmpt, W., Wierts, R., Windhorst, A. D., Mottaghy, F., … Boellaard, R. (2016). Pharmacokinetic modeling of a novel hypoxia PET tracer [18F]HX4 in patients with non-small cell lung cancer. EJNMMI Physics, 3, [30]. https://doi.org/10.1186/s40658-016-0167-y
  90. Eekers, D. B. P., Roelofs, E., Jelen, U., Kirk, M., Granzier, M., Ammazzalorso, F., … Lambin, P. (2016). Benefit of particle therapy in re-irradiation of head and neck patients. Results of a multicentric in silico ROCOCO trial. Radiotherapy and Oncology, 121(3), 387-394. https://doi.org/10.1016/j.radonc.2016.08.020
  91. Jochems, A., Deist, T. M., van Soest, J., Eble, M., Bulens, P., Coucke, P., … Dekker, A. (2016). Distributed learning: Developing a predictive model based on data from multiple hospitals without data leaving the hospital – A real life proof of concept. Radiotherapy and Oncology, 121(3), 459-467. https://doi.org/10.1016/j.radonc.2016.10.002
  92. De Ruysscher, D., Defraene, G., Ramaekers, B. L. T., Lambin, P., Briers, E., Stobart, H., … West, C. (2016). Optimal design and patient selection for interventional trials using radiogenomic biomarkers: A REQUITE and Radiogenomics consortium statement. Radiotherapy and Oncology, 121(3), 440-446. https://doi.org/10.1016/j.radonc.2016.11.003
  93. van Timmeren, J. E., Leijenaar, R. T. H., van Elmpt, W., Wang, J., Zhang, Z., Dekker, A., & Lambin, P. (2016). Test-Retest Data for Radiomics Feature Stability Analysis: Generalizable or Study-Specific? TOMOGRAPHY, 2(4), 361-365. https://doi.org/10.18383/j.tom.2016.00208
  94. Zegers, K., Hoebers, F. J. P., van Elmpt, W., Bons, J. A., Öllers, M., Troost, E. G. C., … Lambin, P. (2016). Evaluation of tumour hypoxia during radiotherapy using [F-18]HX4 PET imaging and blood biomarkers in patients with head and neck cancer. European Journal of Nuclear Medicine and Molecular Imaging, 43(12), 2139-2146. https://doi.org/10.1007/s00259-016-3429-y
  95. Rekers, N. H., Pimentel, V. O., Yaromina, A., Dubois, L., & Lambin, P. (2016). IL2 based immunotherapies: towards a personalized and curative antitumor response. Translational Cancer Research, 5(Suppl 6), S1292-S1294. https://doi.org/10.21037/tcr.2016.11.26
  96. Martinussen, H. M. A., Reymen, B., Wanders, R., Troost, E. G. C., Dingemans, A-M. C., Öllers, M., … van Baardwijk – Renkens, A. (2016). Is selective nodal irradiation in non-small cell lung cancer still safe when using IMRT? Results of a prospective cohort study. Radiotherapy and Oncology, 121(2), 322-327. https://doi.org/10.1016/j.radonc.2016.10.001
  97. Vanneste, B. G. L., Hoffmann, A. L., van Lin, E. N., Van de Voorde, L., Pinkawa, M., & Lambin, P. (2016). Who will benefit most from hydrogel rectum spacer implantation in prostate cancer radiotherapy? A model-based approach for patient selection. Radiotherapy and Oncology, 121(1), 118-123. https://doi.org/10.1016/j.radonc.2016.08.026
  98. Larue, R. T. H. M., Van de Voorde, L., Berbee, M., van Elmpt, W. J. C., Dubois, L. J., Panth, K. M., … Lambin, P. (2016). A phase 1 ‘window-of-opportunity’ trial testing evofosfamide (TH-302), a tumour-selective hypoxia-activated cytotoxic prodrug, with preoperative chemoradiotherapy in oesophageal adenocarcinoma patients. BMC Cancer, 16, [644]. https://doi.org/10.1186/s12885-016-2709-z
  99. van Kuijk, S. J. A., Gieling, R. G., Niemans, R., Lieuwes, N. G., Biemans, R., Telfer, B. A., … Williams, K. J. (2016). The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy. PLOS ONE, 11(8), [e0161040]. https://doi.org/10.1371/journal.pone.0161040
  100. Habets, T. H. P. M., Oth, T., Houben, A., Huijskens, M. J. A. J., Senden-Gijsbers, B. L. M. G., Schnijderberg, M. C. A., … Vanderlocht, J. (2016). Fractionated Radiotherapy with 3 x 8 Gy Induces Systemic Anti-Tumour Responses and Abscopal Tumour Inhibition without Modulating the Humoral Anti-Tumour Response. PLOS ONE, 11(7), [e0159515]. https://doi.org/10.1371/journal.pone.0159515
  101. Sneddon, D., Niemans, R., Bauwens, M., Yaromina, A., van Kuijk, S. J. A., Lieuwes, N. G., … Poulsen, S-A. (2016). Synthesis and in Vivo Biological Evaluation of Ga-68-Labeled Carbonic Anhydrase IX Targeting Small Molecules for Positron Emission Tomography. Journal of Medicinal Chemistry, 59(13), 6431-6443. https://doi.org/10.1021/acs.jmedchem.6b00623
  102. Mowday, A. M., Guise, C. P., Ackerley, D. F., Minton, N. P., Lambin, P., Dubois, L. J., … Patterson, A. V. (2016). Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress. Cancers, 8(7), [63]. https://doi.org/10.3390/cancers8070063
  103. van Gisbergen, M. W., Cebula, M., Zhang, J., Ottosson-Wadlund, A., Dubois, L., Lambin, P., … Johansson, K. (2016). Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells. Molecular Pharmaceutics, 13(6), 2010-2025. https://doi.org/10.1021/acs.molpharmaceut.6b00140
  104. Carvalho, S., Troost, E. G. C., Bons, J., Menheere, P., Lambin, P., & Oberije, C. (2016). Prognostic value of blood-biomarkers related to hypoxia, inflammation, immune response and tumour load in non-small cell lung cancer – A survival model with external validation. Radiotherapy and Oncology, 119(3), 487-494. https://doi.org/10.1016/j.radonc.2016.04.024
  105. Compter, I., Peerlings, J., Eekers, D. B. P., Postma, A. A., Ivanov, D., Wiggins, C. J., … Hoffmann, A. L. (2016). Technical feasibility of integrating 7 T anatomical MRI in image-guided radiotherapy of glioblastoma: a preparatory study. Magnetic Resonance Materials in Physics Biology and Medicine, 29(3), 591–603. https://doi.org/10.1007/s10334-016-0534-7
  106. CTMM Air Force Consortium, & Lambin, P. (2016). Total Body Metabolic Tumor Response in ALK Positive Non-Small Cell Lung Cancer Patients Treated with ALK Inhibition. PLOS ONE, 11(5), [e0149955]. https://doi.org/10.1371/journal.pone.0149955
  107. Widder, J., van der Schaaf, A., Lambin, P., Marijnen, C. A. M., Pignol, J-P., Rasch, C. R., … Langendijk, J. A. (2016). The Quest for Evidence for Proton Therapy: Model-Based Approach and Precision Medicine. International Journal of Radiation Oncology Biology Physics, 95(1), 30-36. https://doi.org/10.1016/j.ijrobp.2015.10.004
  108. Wu, W., Parmar, C., Grossmann, P., Quackenbush, J., Lambin, P., Bussink, J., … Aerts, H. J. W. L. (2016). Exploratory Study to Identify Radiomics Classifiers for Lung Cancer Histology. Frontiers in Oncology, 6, [71]. https://doi.org/10.3389/fonc.2016.00071
  109. van Kuijk, S. J. A., Yaromina, A., Houben, R., Niemans, R., Lambin, P., & Dubois, L. J. (2016). Prognostic Significance of Carbonic Anhydrase IX expression in Cancer Patients: A Meta-Analysis. Frontiers in Oncology, 6, [69]. https://doi.org/10.3389/fonc.2016.00069
  110. Panth, K. M., van den Beucken, T., Biemans, R., Lieuwes, N. G., Weber, M., Losen, M., … Lambin, P. (2016). In vivo optical imaging of MMP2 immuno protein antibody: tumor uptake is associated with MMP2 activity. Scientific Reports, 6, [22198]. https://doi.org/10.1038/srep22198
  111. Braam, P., Lambin, P., & Bussink, J. (2016). Stereotactic versus conventional radiotherapy for pain reduction and quality of life in spinal metastases: study protocol for a randomized controlled trial. Trials, 17, [61]. https://doi.org/10.1186/s13063-016-1178-7
  112. Sharifi, H., Van Elmpt, W., Oberije, C., Nalbantov, G., Das, M., Öllers, M., … De Ruysscher, D. (2016). Quantification of CT-assessed radiation-induced lung damage in lung cancer patients treated with or without chemotherapy and cetuximab. Acta Oncologica, 55(2), 156-162. https://doi.org/10.3109/0284186X.2015.1080856
  113. Walsh, S., Roelofs, E., Kuess, P., Lambin, P., Jones, B., Georg, D., & Verhaegen, F. (2016). A validated tumor control probability model based on a meta-analysis of low, intermediate, and high-risk prostate cancer patients treated by photon, proton, or carbon-ion radiotherapy. Medical Physics, 43(2), 734-747. https://doi.org/10.1118/1.4939260
  114. Cheng, Q., Roelofs, E., Ramaekers, B. L. T., Eekers, D., van Soest, J., Lustberg, T., … Lambin, P. (2016). Development and evaluation of an online three-level proton vs photon decision support prototype for head and neck cancer – Comparison of dose, toxicity and cost-effectiveness. Radiotherapy and Oncology, 118(2), 281-285. https://doi.org/10.1016/j.radonc.2015.12.029
  115. Zindler, J. D., Thomas, C. R. . J., Hahn, S. M., Hoffmann, A. L., Troost, E. G. C., & Lambin, P. (2016). Increasing the Therapeutic Ratio of Stereotactic Ablative Radiotherapy by Individualized Isotoxic Dose Prescription. Journal of the National Cancer Institute, 108(2), [djv305]. https://doi.org/10.1093/jnci/djv305
  116. van Elmpt, W., Zegers, K., Reymen, B., Even, A. J. G., Dingemans, A-M. C., Öllers, M., … Lambin, P. (2016). Multiparametric imaging of patient and tumour heterogeneity in non-small-cell lung cancer: quantification of tumour hypoxia, metabolism and perfusion. European Journal of Nuclear Medicine and Molecular Imaging, 43(2), 240-248. https://doi.org/10.1007/s00259-015-3169-4
  117. Bongers, M. L., de Ruysscher, D., Oberije, C., Lambin, P., Uyl-de Groot, C. A., & Coupe, V. M. H. (2016). Multistate Statistical Modeling: A Tool to Build a Lung Cancer Microsimulation Model That Includes Parameter Uncertainty and Patient Heterogeneity. Medical Decision Making, 36(1), 86-100. https://doi.org/10.1177/0272989X15574500
  118. Jacobs, M., Boersma, L., Merode, F. V., Dekker, A., Verhaegen, F., Linden, L., & Lambin, P. (2016). How efficient is translational research in radiation oncology? The example of a large Dutch academic radiation oncology department. British Journal of Radiology, 89(1064), [20160129]. https://doi.org/10.1259/bjr.20160129
  119. Vanneste, B. G. L., Van Limbergen, E. J., van Lin, E. N., van Roermund, J. G. H., & Lambin, P. (2016). Prostate Cancer Radiation Therapy: What Do Clinicians Have to Know? BioMed Research International, 2016, [6829875]. https://doi.org/10.1155/2016/6829875
  120. Meldolesi, E., van Soest, J., Damiani, A., Dekker, A., Alitto, A. R., Campitelli, M., … Valentini, V. (2016). Standardized data collection to build prediction models in oncology: a prototype for rectal cancer. Future Oncology, 12(1), 119-136. https://doi.org/10.2217/fon.15.295
  121. Jacobs, M., Boersma, L., Dekker, A., Bosmans, G., van Merode, F., Verhaegen, F., … Lambin, P. (2016). What is the degree of innovation routinely implemented in Dutch radiotherapy centres? A multicentre cross-sectional study. British Journal of Radiology, 89, [20160601]. https://doi.org/10.1259/bjr.20160601
  122. 2015
  123. Trani, D., Yaromina, A., Dubois, L., Granzier, M., Peeters, S. G. J. A., Biemans, R., … Lambin, P. (2015). Preclinical Assessment of Efficacy of Radiation Dose Painting Based on Intratumoral FDG-PET Uptake. Clinical Cancer Research, 21(24), 5511-5518. https://doi.org/10.1158/1078-0432.CCR-15-0290
  124. Parmar, C., Grossmann, P., Rietveld, D., Rietbergen, M. M., Lambin, P., & Aerts, H. J. W. L. (2015). Radiomic Machine-Learning Classifiers for Prognostic Biomarkers of Head and Neck Cancer. Frontiers in Oncology, 5, [272]. https://doi.org/10.3389/fonc.2015.00272
  125. Van De Voorde, L., Larue, R., Persoon, L., Oelers, M., Nijsten, S., Bosmans, G., … Lambin, P. (2015). The influence of gastric filling instructions on dose delivery in patients with oesophageal cancer: A prospective study. In Radiotherapy and Oncology (Radiotherapy and Oncology). Elsevier Ireland Ltd. https://doi.org/10.1016/j.radonc.2015.09.006
  126. van der Valk, F. M., Sluimer, J. C., Voo, S. A., Verberne, H. J., Nederveen, A. J., Windhorst, A. D., … Daemen, M. J. A. P. (2015). In Vivo Imaging of Hypoxia in Atherosclerotic Plaques in Humans. JACC-Cardiovascular Imaging, 8(11), 1340-1341. https://doi.org/10.1016/j.jcmg.2014.12.015
  127. Zegers, C. M. L., van Elmpt, W., Szardenings, K., Kolb, H., Waxman, A., Subramaniam, R. M., … Chien, D. (2015). Repeatability of hypoxia PET imaging using [F-18]HX4 in lung and head and neck cancer patients: a prospective multicenter trial. European Journal of Nuclear Medicine and Molecular Imaging, 42(12), 1840-1849. https://doi.org/10.1007/s00259-015-3100-z
  128. Leijenaar, R. T. H., Carvalho, S., Hoebers, F. J. P., Aerts, H. J. W. L., Van Elmpt, W. J. C., Huang, S. H., … Lambin, P. (2015). External validation of a prognostic CT-based radiomic signature in oropharyngeal squamous cell carcinoma. Acta Oncologica, 54(9), 1423-1429. https://doi.org/10.3109/0284186X.2015.1061214
  129. Zegers, C. M. L., Van Elmpt, W., Hoebers, F. J. P., Troost, E. G. C., Ollers, M. C., Mottaghy, F. M., & Lambin, P. (2015). Imaging of tumour hypoxia and metabolism in patients with head and neck squamous cell carcinoma. Acta Oncologica, 54(9), 1378-1384. https://doi.org/10.3109/0284186X.2015.1062913
  130. Lambin, P., Zindler, J., Vanneste, B., Van De Voorde, L., Jacobs, M., Eekers, D., … Walsh, S. (2015). Modern clinical research: How rapid learning health care and cohort multiple randomised clinical trials complement traditional evidence based medicine. Acta Oncologica, 54(9), 1289-1300. https://doi.org/10.3109/0284186X.2015.1062136
  131. Dubois, L., Biemans, R., Reniers, B., Bosmans, G., Trani, D., Podesta, M., … Lambin, P. (2015). High dose rate and flattening filter free irradiation can be safely implemented in clinical practice. International Journal of Radiation Biology, 91(10), 778-785. https://doi.org/10.3109/09553002.2015.1068457
  132. Peeters, S. G. J. A., Dubois, L., Lieuwes, N. G., Laan, D., Mooijer, M., Schuit, R. C., … Lambin, P. (2015). [F-18]VM4-037 MicroPET Imaging and Biodistribution of Two In Vivo CAIX-Expressing Tumor Models. Molecular Imaging and Biology, 17(5), 615-619. https://doi.org/10.1007/s11307-015-0831-y
  133. Van de Voorde, L., Janssen, L., Larue, R., Houben, R., Buijsen, J., Sosef, M., … Lambin, P. (2015). Can metformin improve ‘the tomorrow’ of patients treated for oesophageal cancer? European Journal of Surgical Oncology, 41(10), 1333-1339. https://doi.org/10.1016/j.ejso.2015.05.012
  134. Vanneste, B. G. L., van de Voorde, L., de Ridder, R., Van Limbergen, E. J., Lambin, P., & van Lin, E. N. (2015). Chronic radiation proctitis: tricks to prevent and treat. International Journal of Colorectal Disease, 30(10), 1293-1303. https://doi.org/10.1007/s00384-015-2289-4
  135. Ward, C., Meehan, J., Mullen, P., Supuran, C., Dixon, J. M., Thomas, J. S., … Langdon, S. P. (2015). Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models. Oncotarget, 6(28), 24856-24870. https://doi.org/10.18632/oncotarget.4498
  136. Rekers, N. H., Zegers, C. M. L., Yaromina, A., Lieuwes, N. G., Biemans, R., Senden-Gijsbers, B. L. M. G., … Lambin, P. (2015). Combination of radiotherapy with the immunocytokine L19-IL2: Additive effect in a NK cell dependent tumour model. Radiotherapy and Oncology, 116(3), 438-442. https://doi.org/10.1016/j.radonc.2015.06.019
  137. Panth, K. M., Leijenaar, R. T. H., Carvalho, S., Lieuwes, N. G., Yaromina, A., Dubois, L., & Lambin, P. (2015). Is there a causal relationship between genetic changes and radiomics-based image features? An in vivo preclinical experiment with doxycycline inducible GADD34 tumor cells. Radiotherapy and Oncology, 116(3), 462-466. https://doi.org/10.1016/j.radonc.2015.06.013
  138. Dubois, L. J., Niemans, R., van Kuijk, S. J. A., Panth, K. M., Parvathaneni, N-K., Peeters, S. G. J. A., … Lambin, P. (2015). New ways to image and target tumour hypoxia and its molecular responses. Radiotherapy and Oncology, 116(3), 352-357. https://doi.org/10.1016/j.radonc.2015.08.022
  139. Parmar, C., Grossmann, P., Bussink, J., Lambin, P., & Aerts, H. J. W. L. (2015). Machine Learning methods for Quantitative Radiomic Biomarkers. Scientific Reports, 5, [13087]. https://doi.org/10.1038/srep13087
  140. Leijenaar, R. T. H., Nalbantov, G., Carvalho, S., van Elmpt, W. J. C., Troost, E. G. C., Boellaard, R., … Lambin, P. (2015). The effect of SUV discretization in quantitative FDG-PET Radiomics: the need for standardized methodology in tumor texture analysis. Scientific Reports, 5, [11075]. https://doi.org/10.1038/srep11075
  141. Rekers, N. H., Zegers, C. M. L., Germeraad, W. T., Dubois, L., & Lambin, P. (2015). Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2. OncoImmunology , 4(8), e1021541. https://doi.org/10.1080/2162402X.2015.1021541
  142. Even, A. J. G., van der Stoep, J., Zegers, C. M. L., Reymen, B., Troost, E. G. C., Lambin, P., & van Elmpt, W. (2015). PET-based dose painting in non-small cell lung cancer: Comparing uniform dose escalation with boosting hypoxic and metabolically active sub-volumes. Radiotherapy and Oncology, 116(2), 281-286. https://doi.org/10.1016/j.radonc.2015.07.013
  143. Oberije, C., De Ruysscher, D., Houben, R., van de Heuvel, M., Uyterlinde, W., Deasy, J. O., … Lambin, P. (2015). A Validated Prediction Model for Overall Survival From Stage III Non-Small Cell Lung Cancer: Toward Survival Prediction for Individual Patients. International Journal of Radiation Oncology Biology Physics, 92(4), 935-944. https://doi.org/10.1016/j.ijrobp.2015.02.048
  144. Peeters, S. G. J. A., Zegers, C. M. L., Biemans, R., Lieuwes, N. G., van Stiphout, R. G. P. M., Yaromina, A., … Lambin, P. (2015). TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [F-18]HX4 Hypoxia PET Imaging. Clinical Cancer Research, 21(13), 2984-2992. https://doi.org/10.1158/1078-0432.CCR-15-0018
  145. Boutros, P. C., Fraser, M., Harding, N. J., de Borja, R., Trudel, D., Lalonde, E., … Bristow, R. G. (2015). Spatial genomic heterogeneity within localized, multifocal prostate cancer. Nature Genetics, 47(7), 736-+. https://doi.org/10.1038/ng.3315
  146. Parmar, C., Leijenaar, R. T. H., Grossmann, P., Velazquez, E. R., Bussink, J., Rietveld, D., … Aerts, H. J. W. L. (2015). Radiomic feature clusters and Prognostic Signatures specific for Lung and Head & Neck cancer. Scientific Reports, 5, [11044]. https://doi.org/10.1038/srep11044
  147. Rietbergen, M. M., Witte, B. I., Velazquez, E. R., Snijders, P. J. F., Bloemena, E., Speel, E. J., … Leemans, C. R. (2015). Different prognostic models for different patient populations: validation of a new prognostic model for patients with oropharyngeal cancer in Western Europe. British Journal of Cancer, 112(11), 1733-1736. https://doi.org/10.1038/bjc.2015.139
  148. van Gijn, W., van Stiphout, R. G. P. M., van de Velde, C. J. H., Valentini, V., Lammering, G., Gambacorta, M. A., … Lambin, P. (2015). Nomograms to predict survival and the risk for developing local or distant recurrence in patients with rectal cancer treated with optional short-term radiotherapy. Annals of Oncology, 26(5), 928-935. https://doi.org/10.1093/annonc/mdv023
  149. Trani, D., Reniers, B., Persoon, L., Podesta, M., Nalbantov, G., Leijenaar, R. T. H., … Lambin, P. (2015). What Level of Accuracy Is Achievable for Preclinical Dose Painting Studies on a Clinical Irradiation Platform? Radiation Research, 183(5), 501-510. https://doi.org/10.1667/RR13933.1
  150. Bongers, M. L., Coupe, V. M. H., De Ruysscher, D., Oberije, C., Lambin, P., & Uyl-de Groot, C. A. (2015). Individualized Positron Emission Tomography-Based Isotoxic Accelerated Radiation Therapy Is Cost-Effective Compared With Conventional Radiation Therapy: A Model-Based Evaluation. International Journal of Radiation Oncology Biology Physics, 91(4), 857-865. https://doi.org/10.1016/j.ijrobp.2014.12.012
  151. Starmans, M. H. W., Pintilie, M., Chan-Seng-Yue, M., Moon, N. C., Haider, S., Nguyen, F., … Boutros, P. C. (2015). Integrating RAS Status into Prognostic Signatures for Adenocarcinomas of the Lung. Clinical Cancer Research, 21(6), 1477-1486. https://doi.org/10.1158/1078-0432.CCR-14-1749
  152. Grove, O., Berglund, A. E., Schabath, M. B., Aerts, H. J. W. L., Dekker, A., Wang, H., … Gillies, R. J. (2015). Quantitative Computed Tomographic Descriptors Associate Tumor Shape Complexity and Intratumor Heterogeneity with Prognosis in Lung Adenocarcinoma. PLOS ONE, 10(3), [e0118261]. https://doi.org/10.1371/journal.pone.0118261
  153. Creutzberg, C. L., van Stiphout, R. G. P. M., Nout, R. A., Lutgens, L. C. H. W., Juergenliemk-Schulz, I. M., Jobsen, J. J., … Lambin, P. (2015). Nomograms for Prediction of Outcome With or Without Adjuvant Radiation Therapy for Patients With Endometrial Cancer: A Pooled Analysis of PORTEC-1 and PORTEC-2 Trials. International Journal of Radiation Oncology Biology Physics, 91(3), 530-539. https://doi.org/10.1016/j.ijrobp.2014.11.022
  154. Coroller, T. P., Grossmann, P., Hou, Y., Velazquez, E. R., Leijenaar, R. T. H., Hermann, G., … Aerts, H. J. W. L. (2015). CT-based radiomic signature predicts distant metastasis in lung adenocarcinoma. Radiotherapy and Oncology, 114(3), 345-350. https://doi.org/10.1016/j.radonc.2015.02.015
  155. Peeters, S. G. J. A., Zegers, C. M. L., Yaromina, A., Van Elmpt, W., Dubois, L., & Lambin, P. (2015). Current preclinical and clinical applications of hypoxia PET imaging using 2-nitroimidazoles. Quarterly Journal of Nuclear Medicine and Molecular Imaging, 59(1), 39-57.
  156. Zegers, C. M. L., Rekers, N. H., Quaden, D. H. F., Lieuwes, N. G., Yaromina, A., Germeraad, W. T. V., … Lambin, P. (2015). Radiotherapy Combined with the Immunocytokine L19-IL2 Provides Long-lasting Antitumor Effects. Clinical Cancer Research, 21(5), 1151-1160. https://doi.org/10.1158/1078-0432.CCR-14-2676
  157. Valentini, V., van Stiphout, R. G. P. M., Lammering, G., Gambacorta, M. A., Barba, M. C., Bebenek, M., … Lambin, P. (2015). Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer. Radiotherapy and Oncology, 114(3), 302-309. https://doi.org/10.1016/j.radonc.2015.02.001
  158. Peeters, S. G. J. A., Zegers, C. M. L., Lieuwes, N. G., van Elmpt, W., Eriksson, J., van Dongen, G. A. M. S., … Lambin, P. (2015). A Comparative Study of the Hypoxia PET Tracers [F-18] HX4, [F-18] FAZA, and [F-18] FMISO in a Preclinical Tumor Model. International Journal of Radiation Oncology Biology Physics, 91(2), 351-359. https://doi.org/10.1016/j.ijrobp.2014.09.045
  159. Toma-Dasu, I., Uhrdin, J., Lazzeroni, M., Carvalho, S., van Elmpt, W., Lambin, P., & Dasu, A. (2015). Evaluating Tumor Response of Non-Small Cell Lung Cancer Patients With F-18-Fludeoxyglucose Positron Emission Tomography: Potential for Treatment Individualization. International Journal of Radiation Oncology Biology Physics, 91(2), 376-384. https://doi.org/10.1016/j.ijrobp.2014.10.012
  160. Van De Voorde, L., Vanneste, B., Houben, R., Damen, P., van den Bogaard, J., Lammering, G., … Lambin, P. (2015). Image-guided stereotactic ablative radiotherapy for the liver: A safe and effective treatment. European Journal of Surgical Oncology, 41(2), 249-256. https://doi.org/10.1016/j.ejso.2014.10.053
  161. Buijsen, J., van den Bogaard, J., Jutten, B., Belgers, E., Sosef, M., Leijtens, J. W., … Lambin, P. (2015). A phase I-II study on the combination of rapamycin and short course radiotherapy in rectal cancer. Radiotherapy and Oncology, 116(2), 214-220. https://doi.org/10.1016/j.radonc.2015.07.039
  162. Jacobs, M., Boersma, L., Dekker, A., Govers, M., Lambin, P., & van Merode, F. (2015). How to measure innovation in radiotherapy: an application of the Delphi method. Journal of Hospital Administration, 4(4), 14-23. https://doi.org/10.5430/jha.v4n4p14
  163. Jacobs, M., Boersma, L., Dekker, A., Hermanns, E., Houben, R., Govers, M., … Lambin, P. (2015). Organizational development trajectory of a large academic radiotherapy department set up similarly to a prospective clinical trial: the MAASTRO experience. British Journal of Radiology, 88(1049), [20140559]. https://doi.org/10.1259/bjr.20140559
  164. Vanneste, B. G. L., Pijls-Johannesma, M., van de Voorde, L., van Lin, E. N., van de Beek, K., van Loon, J., … Lambin, P. (2015). Spacers in radiotherapy treatment of prostate cancer: Is reduction of toxicity cost-effective? Radiotherapy and Oncology, 114(2), 276-281. https://doi.org/10.1016/j.radonc.2015.01.005
  165. Yao, C. Q., Francis Nguyen, Haider, S., Starmans, M. H. W., Lambin, P., & Boutros, P. C. (2015). The transcriptomic profile of ovarian cancer grading. Cancer Medicine, 4(1), 56-64. https://doi.org/10.1002/cam4.343
  166. Theys, J., & Lambin, P. (2015). Clostridium to treat cancer: dream or reality? Annals of translational medicine, 3(Suppl 1), S21. https://doi.org/10.3978/j.issn.2305-5839.2015.03.39
  167. van Gisbergen, M. W., Voets, A. M., Starmans, M. H. W., de Coo, I. F. M., Yadak, R., Hoffmann, R. F., … Lambin, P. (2015). How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models. Mutation Research-Reviews in Mutation Research, 764, 16-30. https://doi.org/10.1016/j.mrrev.2015.01.001
  168. Fontanarosa, D., Witte, M., Meijer, G., Shakirin, G., Steenhuijsen, J., Schuring, D., … Lambin, P. (2015). Probabilistic evaluation of target dose deterioration in dose painting by numbers for stage II/III lung cancer. Practical radiation oncology, 5(4), e375-e382. https://doi.org/10.1016/j.prro.2015.01.001
  169. Pettersen, E. O., Ebbesen, P., Gieling, R. G., Williams, K. J., Dubois, L., Lambin, P., … Cojocari, D. (2015). Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium. Journal of Enzyme Inhibition and Medicinal Chemistry, 30(5), 689-721. https://doi.org/10.3109/14756366.2014.966704
  170. 2014
  171. Zegers, C. M. L., Van Elmpt, W., Reymen, B., Even, A. J. G., Troost, E. G. C., Oelers, M. C., … Lambin, P. (2014). In vivo quantification of hypoxic and metabolic status of NSCLC tumors using [18f]hx4 and [18f]fdg-pet/ct imaging. Clinical Cancer Research, 20(24), 6389-6397. https://doi.org/10.1158/1078-0432.CCR-14-1524
  172. Skripcak, T., Belka, C., Bosch, W., Brink, C., Brunner, T., Budach, V., … Baumann, M. (2014). Creating a data exchange strategy for radiotherapy research: Towards federated databases and anonymised public datasets. Radiotherapy and Oncology, 113(3), 303-309. https://doi.org/10.1016/j.radonc.2014.10.001
  173. Rios Velazquez, E., Hoebers, F., Aerts, H. J. W. L., Rietbergen, M. M., Brakenhoff, R. H., Leemans, R. C., … Lambin, P. (2014). Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than TNM staging. Radiotherapy and Oncology, 113(3), 324-30. https://doi.org/10.1016/j.radonc.2014.09.005
  174. West, C., Azria, D., Chang-Claude, J., Davidson, S., Lambin, P., Rosenstein, B., … Yuille, M. (2014). The REQUITE Project: Validating Predictive Models and Biomarkers of Radiotherapy Toxicity to Reduce Side-effects and Improve Quality of Life in Cancer Survivors. Clinical oncology, 26(12), 739-742. https://doi.org/10.1016/j.clon.2014.09.008
  175. Van De Voorde, L., Larue, R. T. H. M., Pijls, M., Buijsen, J., Troost, E. G. C., Berbée, M., … Lambin, P. (2014). A qualitative synthesis of the evidence behind elective lymph node irradiation in oesophageal cancer. Radiotherapy and Oncology, 113(2), 166-74. https://doi.org/10.1016/j.radonc.2014.11.010
  176. van Stiphout, R. G. P. M., Valentini, V., Buijsen, J., Lammering, G., Meldolesi, E., van Soest, J., … Lambin, P. (2014). Nomogram predicting response after chemoradiotherapy in rectal cancer using sequential PETCT imaging: A multicentric prospective study with external validation. Radiotherapy and Oncology, 113(2), 215-222. https://doi.org/10.1016/j.radonc.2014.11.002
  177. De Ruyck, K., Duprez, F., Ferdinande, L., Mbah, C., Rios-Velazquez, E., Hoebers, F., … Thierens, H. (2014). A let-7 microRNA polymorphism in the KRAS 3′-UTR is prognostic in oropharyngeal cancer. Cancer Epidemiology, 38(5), 591-8. https://doi.org/10.1016/j.canep.2014.07.008
  178. Dekker, A., Vinod, S., Holloway, L., Oberije, C., George, A., Goozee, G., … Thwaites, D. (2014). Rapid learning in practice: a lung cancer survival decision support system in routine patient care data. Radiotherapy and Oncology, 113(1), 47-53. https://doi.org/10.1016/j.radonc.2014.08.013
  179. Rekers, N. H., Troost, E. G. C., Zegers, C. M. L., Germeraad, W. T. V., Dubois, L. J., & Lambin, P. (2014). Stereotactic ablative body radiotherapy combined with immunotherapy: Present status and future perspectives. Cancer Radiotherapie, 18(5-6), 391-395. https://doi.org/10.1016/j.canrad.2014.06.012
  180. Parmar, C., Velazquez, E. R., Leijenaar, R., Jermoumi, M., Carvalho, S., Mak, R. H., … Aerts, H. J. W. L. (2014). Robust Radiomics Feature Quantification Using Semiautomatic Volumetric Segmentation. PLOS ONE, 9(7). https://doi.org/10.1371/journal.pone.0102107
  181. Oberije, C., Nalbantov, G., Dekker, A., Boersma, L., Borger, J., Reymen, B., … Lambin, P. (2014). A prospective study comparing the predictions of doctors versus models for treatment outcome of lung cancer patients: A step toward individualized care and shared decision making. Radiotherapy and Oncology, 112(1), 37-43. https://doi.org/10.1016/j.radonc.2014.04.012
  182. Fox, N. S., Starmans, M. H. W., Haider, S., Lambin, P., & Boutros, P. C. (2014). Ensemble analyses improve signatures of tumour hypoxia and reveal inter-platform differences. BMC Bioinformatics, 15, [170]. https://doi.org/10.1186/1471-2105-15-170
  183. Aerts, H. J. W. L., Velazquez, E. R., Leijenaar, R. T. H., Parmar, C., Grossmann, P., Cavalho, S., … Lambin, P. (2014). Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach. Nature Communications, 5, [4006]. https://doi.org/10.1038/ncomms5006
  184. Dingemans, A-M. C., Bootsma, G., van Baardwijk, A., Reymen, B., Wanders, R., Brans, B., … de Ruysscher, D. (2014). A Phase I Study of Concurrent Individualized, Isotoxic Accelerated Radiotherapy and Cisplatin-Vinorelbine-Cetuximab in Patients With Stage III Non-Small-Cell Lung Cancer. Journal of Thoracic Oncology, 9(5), 710-716. https://doi.org/10.1097/JTO.0000000000000151
  185. Buijsen, J., van Stiphout, R. G., Menheere, P. P., Lammering, G., & Lambin, P. (2014). Blood biomarkers are helpful in the prediction of response to chemoradiation in rectal cancer: a prospective, hypothesis driven study on patients with locally advanced rectal cancer. Radiotherapy and Oncology, 111(2), 237-242. https://doi.org/10.1016/j.radonc.2014.03.006
  186. Smits, K. M., Melotte, V., Niessen, H. E. C., Dubois, L., Oberije, C., Troost, E. G. C., … Lambin, P. (2014). Epigenetics in radiotherapy: Where are we heading? Radiotherapy and Oncology, 111(2), 168-177. https://doi.org/10.1016/j.radonc.2014.05.001
  187. Phillips, M., Beatty, J. D., Cataneo, R. N., Huston, J., Kaplan, P. D., Lalisang, R. I., … Patel, U. (2014). Rapid Point-Of-Care Breath Test for Biomarkers of Breast Cancer and Abnormal Mammograms. PLOS ONE, 9(3), [e90226]. https://doi.org/10.1371/journal.pone.0090226
  188. Reymen, B., van Baardwijk, A., Wanders, R., Borger, J., Dingemans, A-M. C., Bootsma, G., … De Ruysscher, D. (2014). Long-term survival of stage T4N0-1 and single station IIIA-N2 NSCLC patients treated with definitive chemo-radiotherapy using individualised isotoxic accelerated radiotherapy (INDAR). Radiotherapy and Oncology, 110(3), 482-487. https://doi.org/10.1016/j.radonc.2013.12.005
  189. Hoeben, B. A. W., Starmans, M. H. W., Leijenaar, R. T. H., Dubois, L. J., van der Kogel, A. J., Kaanders, J. H. A. M., … Bussink, J. (2014). Systematic analysis of F-18-FDG PET and metabolism, proliferation and hypoxia markers for classification of head and neck tumors. BMC Cancer, 14, [130]. https://doi.org/10.1186/1471-2407-14-130
  190. Roelofs, E., Dekker, A., Meldolesi, E., van Stiphout, R. G. P. M., Valentini, V., & Lambin, P. (2014). International data-sharing for radiotherapy research: An open-source based infrastructure for multicentric clinical data mining. Radiotherapy and Oncology, 110(2), 370-374. https://doi.org/10.1016/j.radonc.2013.11.001
  191. Schlijper, R. C. J., Grutters, J. P. C., Houben, R., Dingemans, A-M. C., Wildberger, J. E., Van Raemdonck, D., … De Ruysscher, D. (2014). What to choose as radical local treatment for lung metastases from cob-rectal cancer: Surgery or radiofrequency ablation? Cancer Treatment Reviews, 40(1), 60-67. https://doi.org/10.1016/j.ctrv.2013.05.004
  192. Marsch, E., Theelen, T. L., Demandt, J. A., Jeurissen, M., van Gink, M., Verjans, R., … Sluimer, J. C. (2014). Reversal of hypoxia in murine atherosclerosis prevents necrotic core expansion by enhancing efferocytosis. Arteriosclerosis Thrombosis and Vascular Biology, 34(12), 2545-2553. https://doi.org/10.1161/ATVBAHA.114.304023
  193. Akurathi, V., Dubois, L., Celen, S., Lieuwes, N. G., Chitneni, S. K., Cleynhens, B. J., … Bormans, G. M. (2014). Development and biological evaluation of Tc-99m-sulfonamide derivatives for in vivo visualization of CA IX as surrogate tumor hypoxia markers. European Journal of Medicinal Chemistry, 71, 374-384. https://doi.org/10.1016/j.ejmech.2013.10.027
  194. Wink, K. C. J., Roelofs, E., Solberg, T., Lin, L., Simone, C. B., Jakobi, A., … Troost, E. G. C. (2014). Particle therapy for non-small cell lung tumors: where do we stand? A systematic review of the literature. Frontiers in Oncology, 4, [292]. https://doi.org/10.3389/fonc.2014.00292
  195. 2013
  196. Velazquez, E. R., Parmar, C., Jermoumi, M., Mak, R. H., van Baardwijk, A., Fennessy, F. M., … Aerts, H. J. W. L. (2013). Volumetric CT-based segmentation of NSCLC using 3D-Slicer. Scientific Reports, 3, [3529]. https://doi.org/10.1038/srep03529
  197. Fontanarosa, D., van der Laan, H. P., Witte, M., Shakirin, G., Roelofs, E., Langendijk, J. A., … van Herk, M. (2013). An in silico comparison between margin-based and probabilistic target-planning approaches in head and neck cancer patients. Radiotherapy and Oncology, 109(3), 430-436. https://doi.org/10.1016/j.radonc.2013.07.012
  198. Rami, M., Dubois, L., Parvathaneni, N-K., Alterio, V., van Kuijk, S. J. A., Monti, S. M., … Winum, J-Y. (2013). Hypoxia-Targeting Carbonic Anhydrase IX Inhibitors by a New Series of Nitroimidazole-Sulfonamides/Sulfamides/Sulfamates. Journal of Medicinal Chemistry, 56(21), 8512-8520. https://doi.org/10.1021/jm4009532
  199. Nalbantov, G., Kietselaer, B., Vandecasteele, K., Oberije, C., Berbee, M., Troost, E., … Lambin, P. (2013). Cardiac comorbidity is an independent risk factor for radiation-induced lung toxicity in lung cancer patients. Radiotherapy and Oncology, 109(1), 100-106. https://doi.org/10.1016/j.radonc.2013.08.035
  200. van Elmpt, W., Das, M., Huellner, M., Sharifi, H., Zegers, C. M. L., Reymen, B., … De Ruysscher, D. (2013). Characterization of tumor heterogeneity using dynamic contrast enhanced CT and FDG-PET in non-small cell lung cancer. Radiotherapy and Oncology, 109(1), 65-70. https://doi.org/10.1016/j.radonc.2013.08.032
  201. Zegers, C. M., van Elmpt, W., Wierts, R., Reymen, B., Sharifi, H., Ollers, M. C., … Lambin, P. (2013). Hypoxia imaging with [18F]HX4 PET in NSCLC patients: Defining optimal imaging parameters☆. Radiotherapy and Oncology, 109(1), 58-64. https://doi.org/10.1016/j.radonc.2013.08.031
  202. Lambin, P., Roelofs, E., Reymen, B., Velazquez, E. R., Buijsen, J., Zegers, C. M. L., … Dekker, A. (2013). ‘Rapid Learning health care in oncology’ – An approach towards decision support systems enabling customised radiotherapy. Radiotherapy and Oncology, 109(1), 159-164. https://doi.org/10.1016/j.radonc.2013.07.007
  203. Theys, J., Yahyanejad, S., Habets, R., Span, P., Dubois, L., Paesmans, K., … Vooijs, M. (2013). High NOTCH activity induces radiation resistance in non small cell lung cancer. Radiotherapy and Oncology, 108(3), 440-445. https://doi.org/10.1016/j.radonc.2013.06.020
  204. Dubois, L., Peeters, S. G. J. A., van Kuijk, S. J. A., Yaromina, A., Lieuwes, N. G., Saraya, R., … Lambin, P. (2013). Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: A new concept of dual targeting drugs. Radiotherapy and Oncology, 108(3), 523-528. https://doi.org/10.1016/j.radonc.2013.06.018
  205. John, T., Starmans, M. H. W., Chen, Y-T., Russell, P. A., Barnett, S. A., White, S. C., … Cebon, J. S. (2013). The Role of Cancer-Testis Antigens as Predictive and Prognostic Markers in Non-Small Cell Lung Cancer. PLOS ONE, 8(7), [e67876]. https://doi.org/10.1371/journal.pone.0067876
  206. Roelofs, E., Persoon, L., Nijsten, S., Wiessler, W., Dekker, A., & Lambin, P. (2013). Benefits of a clinical data warehouse with data mining tools to collect data for a radiotherapy trial. Radiotherapy and Oncology, 108(1), 174-179. https://doi.org/10.1016/j.radonc.2012.09.019
  207. de Smet, M., Hijnen, N. M., Langereis, S., Elevelt, A., Heijman, E., Dubois, L., … Grull, H. (2013). Magnetic Resonance Guided High-Intensity Focused Ultrasound Mediated Hyperthermia Improves the Intratumoral Distribution of Temperature-Sensitive Liposomal Doxorubicin. Investigative Radiology, 48(6), 395-405. https://doi.org/10.1097/RLI.0b013e3182806940
  208. Langendijk, J. A., Lambin, P., De Ruysscher, D., Widder, J., Bos, M., & Verheij, M. (2013). Selection of patients for radiotherapy with protons aiming at reduction of side effects: The model-based approach. Radiotherapy and Oncology, 107(3), 267-273. https://doi.org/10.1016/j.radonc.2013.05.007
  209. Buijsen, J., Lammering, G., Jansen, R. L., Beets, G. L., Wals, J., Sosef, M., … Lambin, P. (2013). Phase I trial of the combination of the Akt inhibitor nelfinavir and chemoradiation for locally advanced rectal cancer. Radiotherapy and Oncology, 107(2), 184-188. https://doi.org/10.1016/j.radonc.2013.03.023
  210. Ramaekers, B. L. T., Grutters, J. P. C., Pijls-Johannesma, M., Lambin, P., Joore, M. A., & Langendijk, J. A. (2013). Protons in Head-and-Neck Cancer: Bridging the Gap of Evidence. International Journal of Radiation Oncology Biology Physics, 85(5), 1282-1288. https://doi.org/10.1016/j.ijrobp.2012.11.006
  211. Reymen, B., Van Loon, J., van Baardwijk, A., Wanders, R., Borger, J., Dingemans, A-M. C., … De Ruysscher, D. (2013). Total Gross Tumor Volume Is an Independent Prognostic Factor in Patients Treated With Selective Nodal Irradiation for Stage I to III Small Cell Lung Cancer. International Journal of Radiation Oncology Biology Physics, 85(5), 1319-1324. https://doi.org/10.1016/j.ijrobp.2012.10.003
  212. Hatt, M., van Stiphout, R., le Pogam, A., Lammering, G., Visvikis, D., & Lambin, P. (2013). Early prediction of pathological response in locally advanced rectal cancer based on sequential F-18-FDG PET. Acta Oncologica, 52(3), 619-626. https://doi.org/10.3109/0284186X.2012.702923
  213. Rouschop, K. M., Dubois, L. J., Keulers, T. G., van den Beucken, T., Lambin, P., Bussink, J., … Wouters, B. G. (2013). PERK/eIF2 alpha signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS. Proceedings of the National Academy of Sciences of the United States of America, 110(12), 4622-4627. https://doi.org/10.1073/pnas.1210633110
  214. Gu, Y., Kumar, V., Hall, L. O., Goldgof, D. B., Li, C-Y., Korn, R., … Gillies, R. J. (2013). Automated delineation of lung tumors from CT images using a single click ensemble segmentation approach. Pattern Recognition, 46(3), 692-702. https://doi.org/10.1016/j.patcog.2012.10.005
  215. De Ruysscher, D., Belderbos, J., Reymen, B., van Elmpt, W., van Baardwijk, A., Wanders, R., … Lambin, P. (2013). State of the Art Radiation Therapy for Lung Cancer 2012: A Glimpse of the Future. Clinical Lung Cancer, 14(2), 89-95. https://doi.org/10.1016/j.cllc.2012.06.006
  216. Heukelom, J., Hamming, O., Bartelink, H., Hoebers, F., Giralt, J., Herlestam, T., … Rasch, C. (2013). Adaptive and innovative Radiation Treatment FOR improving Cancer treatment outcomE (ARTFORCE); a randomized controlled phase II trial for individualized treatment of head and neck cancer. BMC Cancer, 13, [84]. https://doi.org/10.1186/1471-2407-13-84
  217. Lambin, P., van Stiphout, R., Starmans, M. H. W., Rios-Velazquez, E., Nalbantov, G., Aerts, H. J. W. L., … Dekker, A. (2013). Predicting outcomes in radiation oncology-multifactorial decision support systems. Nature Reviews Clinical Oncology, 10(1), 27-40. https://doi.org/10.1038/nrclinonc.2012.196
  218. Carvalho, S., Leijenaar, R. T. H., Velazquez, E. R., Oberije, C., Parmar, C., van Elmpt, W., … Lambin, P. (2013). Prognostic value of metabolic metrics extracted from baseline positron emission tomography images in non-small cell lung cancer. Acta Oncologica, 52(7), 1398-404. https://doi.org/10.3109/0284186X.2013.812795
  219. Leijenaar, R. T. H., Carvalho, S., Velazquez, E. R., van Elmpt, W. J. C., Parmar, C., Hoekstra, O. S., … Lambin, P. (2013). Stability of FDG-PET Radiomics features: an integrated analysis of test-retest and inter-observer variability. Acta oncologica, 52(7), 1391-1397. https://doi.org/10.3109/0284186X.2013.812798
  220. 2012
  221. Voets, A. M., Oberije, C., Struijk, R. B., Reymen, B., De Ruyck, K., Thierens, H., … Lambin, P. (2012). No association between TGF-beta 1 polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer patients. Radiotherapy and Oncology, 105(3), 296-298. https://doi.org/10.1016/j.radonc.2012.09.016
  222. Velazquez, E. R., Aerts, H. J. W. L., Gu, Y., Goldgof, D. B., De Ruysscher, D., Dekker, A., … Lambin, P. (2012). A semiautomatic CT-based ensemble segmentation of lung tumors: Comparison with oncologists’ delineations and with the surgical specimen. Radiotherapy and Oncology, 105(2), 167-173. https://doi.org/10.1016/j.radonc.2012.09.023
  223. van der Heide, U. A., Houweling, A. C., Groenendaal, G., Beets-Tan, R. G. H., & Lambin, P. (2012). Functional MRI for radiotherapy dose painting. Magnetic Resonance Imaging, 30(9), 1216-1223. https://doi.org/10.1016/j.mri.2012.04.010
  224. van Baardwijk, A., Tome, W. A., van Elmpt, W., Bentzen, S. M., Reymen, B., Wanders, R., … De Ruysscher, D. (2012). Is high-dose stereotactic body radiotherapy (SBRT) for stage I non-small cell lung cancer (NSCLC) overkill? A systematic review. Radiotherapy and Oncology, 105(2), 145-149. https://doi.org/10.1016/j.radonc.2012.09.008
  225. van Baardwijk, A., Reymen, B., Wanders, S., Borger, J., Ollers, M., Dingemans, A-M. C., … De Ruysscher, D. (2012). Mature results of a phase II trial on individualised accelerated radiotherapy based on normal tissue constraints in concurrent chemo-radiation for stage III non-small cell lung cancer. European Journal of Cancer, 48(15), 2339-2346. https://doi.org/10.1016/j.ejca.2012.04.014
  226. De Ruysscher, D., Wanders, R., van Baardwijk, A., Dingemans, A-M. C., Reymen, B., Houben, R., … Lambin, P. (2012). Radical Treatment of Non-Small-Cell Lung Cancer Patients with Synchronous Oligometastases Long-Term Results of a Prospective Phase II Trial (Nct01282450). Journal of Thoracic Oncology, 7(10), 1547-1555. https://doi.org/10.1097/JTO.0b013e318262caf6
  227. van Elmpt, W., Ollers, M., Dingemans, A-M. C., Lambin, P., & De Ruysscher, D. (2012). Response Assessment Using F-18-FDG PET Early in the Course of Radiotherapy Correlates with Survival in Advanced-Stage Non-Small Cell Lung Cancer. Journal of Nuclear Medicine, 53(10), 1514-1520. https://doi.org/10.2967/jnumed.111.102566
  228. Starmans, M. H. W., Lieuwes, N. G., Span, P. N., Haider, S., Dubois, L., Nguyen, F., … Lambin, P. (2012). Independent and functional validation of a multi-tumour-type proliferation signature. British Journal of Cancer, 107(3), 508-515. https://doi.org/10.1038/bjc.2012.269
  229. De Ruysscher, D., Van Meerbeeck, J., Vandecasteele, K., Oberije, C., Pijls, M., Dingemans, A. M. C., … De Neve, W. (2012). Radiation-induced oesophagitis in lung cancer patients. Is susceptibility for neutropenia a risk factor? Strahlentherapie Und onkologie, 188(7), 564-567. https://doi.org/10.1007/s00066-012-0098-z
  230. Buijsen, J., van den Bogaard, J., van der Weide, H., Engelsman, S., van Stiphout, R., Janssen, M. P., … Lammering, G. (2012). FDG-PET-CT reduces the interobserver variability in rectal tumor delineation. Radiotherapy and Oncology, 102(3), 371-376. https://doi.org/10.1016/j.radonc.2011.12.016
  231. Lambin, P., Rios-Velazquez, E., Leijenaar, R., Carvalho, S., van Stiphout, R. G. P. M., Granton, P., … Aerts, H. J. W. L. (2012). Radiomics: Extracting more information from medical images using advanced feature analysis. European Journal of Cancer, 48(4), 441-446. https://doi.org/10.1016/j.ejca.2011.11.036
  232. Starmans, M. H. W., Chu, K. C., Haider, S., Francis Nguyen, Seigneuric, R., Magagnin, M. G., … Lambin, P. (2012). The prognostic value of temporal in vitro and in vivo derived hypoxia gene-expression signatures in breast cancer. Radiotherapy and Oncology, 102(3), 436-443. https://doi.org/10.1016/j.radonc.2012.02.002
  233. Janssen, M. H. M., Ollers, M. C., van Stiphout, R. G. P. M., Riedl, R. G., van den Bogaard, J., Buijsen, J., … Lammering, G. (2012). PET-BASED TREATMENT RESPONSE EVALUATION IN RECTAL CANCER: PREDICTION AND VALIDATION. International Journal of Radiation Oncology Biology Physics, 82(2), 871-876. https://doi.org/10.1016/j.ijrobp.2010.11.038
  234. Janssen, M. H. M., Aerts, H. J. W. L., Buijsen, J., Lambin, P., Lammering, G., & Ollers, M. C. (2012). REPEATED POSITRON EMISSION TOMOGRAPHY-COMPUTED TOMOGRAPHY AND PERFUSION-COMPUTED TOMOGRAPHY IMAGING IN RECTAL CANCER: FLUORODEOXYGLUCOSE UPTAKE CORRESPONDS WITH TUMOR PERFUSION. International Journal of Radiation Oncology Biology Physics, 82(2), 849-855. https://doi.org/10.1016/j.ijrobp.2010.10.029
  235. De Ruysscher, D., van Baardwijk, A., Steevens, J., Botterweck, A., Bosmans, G., Reymen, B., … Lambin, P. (2012). Individualised isotoxic accelerated radiotherapy and chemotherapy are associated with improved long-term survival of patients with stage III NSCLC: A prospective population-based study. Radiotherapy and Oncology, 102(2), 228-233. https://doi.org/10.1016/j.radonc.2011.10.010
  236. Aerts, H. J. W. L., Bussink, J., Oyen, W. J. G., van Elmpt, W., Folgering, A. M., Emans, D., … De Ruysscher, D. (2012). Identification of residual metabolic-active areas within NSCLC tumours using a pre-radiotherapy FDG-PET-CT scan: A prospective validation. Lung Cancer, 75(1), 73-76. https://doi.org/10.1016/j.lungcan.2011.06.003
  237. Mul, V. E. M., de Jong, J. M. A., Murrer, L. H. P., van den Ende, P. L. A., Houben, R. M. A., Lacko, M., … Baumert, B. G. (2012). Lhermitte sign and myelopathy after irradiation of the cervical spinal cord in radiotherapy treatment of head and neck cancer. Strahlentherapie Und onkologie, 188(1), 71-76. https://doi.org/10.1007/s00066-011-0010-2
  238. Theelen, A., Martens, J., Bosmans, G., Houben, R., Jager, J. J., Rutten, I., … Baumert, B. G. (2012). Relocatable fixation systems in intracranial stereotactic radiotherapy Accuracy of serial CT scans and patient acceptance in a randomized design. Strahlentherapie Und onkologie, 188(1), 84-90. https://doi.org/10.1007/s00066-011-0018-7
  239. Roelofs, E., Engelsman, M., Rasch, C., Persoon, L., Qamhiyeh, S., de Ruysscher, D., … Lambin, P. (2012). Results of a Multicentric In Silico Clinical Trial (ROCOCO) Comparing Radiotherapy with Photons and Protons for Non-small Cell Lung Cancer. Journal of Thoracic Oncology, 7(1), 165-176. https://doi.org/10.1097/JTO.0b013e31823529fc
  240. van Elmpt, W., Ollers, M., Lambin, P., & De Ruysscher, D. (2012). SHOULD PATIENT SETUP IN LUNG CANCER BE BASED ON THE PRIMARY TUMOR? AN ANALYSIS OF TUMOR COVERAGE AND NORMAL TISSUE DOSE USING REPEATED POSITRON EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY IMAGING. International Journal of Radiation Oncology Biology Physics, 82(1), 379-385. https://doi.org/10.1016/j.ijrobp.2010.09.016
  241. 2011
  242. Starmans, M. H. W., Fung, G., Steck, H., Wouters, B. G., & Lambin, P. (2011). A Simple but Highly Effective Approach to Evaluate the Prognostic Performance of Gene Expression Signatures. PLOS ONE, 6(12), [e28320]. https://doi.org/10.1371/journal.pone.0028320
  243. Wanders, R., Steevens, J., Botterweck, A., Dingemans, A-M. C., Reymen, B., van Baardwijk, A., … De Ruysscher, D. (2011). Treatment with curative intent of stage III non-small cell lung cancer patients of 75 years: A prospective population-based study. European Journal of Cancer, 47(18), 2691-2697. https://doi.org/10.1016/j.ejca.2011.06.023
  244. Petit, S. F., van Elmpt, W. J. C., Oberije, C. J. G., Vegt, E., Dingemans, A-M. C., Lambin, P., … De Ruysscher, D. (2011). [¹⁸F]fluorodeoxyglucose uptake patterns in lung before radiotherapy identify areas more susceptible to radiation-induced lung toxicity in non-small-cell lung cancer patients. International Journal of Radiation Oncology Biology Physics, 81(3), 698-705. https://doi.org/10.1016/j.ijrobp.2010.06.016
  245. Hatt, M., Cheze-le Rest, C., van Baardwijk, A., Lambin, P., Pradier, O., & Visvikis, D. (2011). Impact of Tumor Size and Tracer Uptake Heterogeneity in F-18-FDG PET and CT Non-Small Cell Lung Cancer Tumor Delineation. Journal of Nuclear Medicine, 52(11), 1690-1697. https://doi.org/10.2967/jnumed.111.092767
  246. Dehing-Oberije, C. J. G., Aerts, H., Yu, S., de Ruysscher, D., Menheere, P. P. C. A., Hilvo, M., … Lambin, P. (2011). Development and Validation of a Prognostic Model Using Blood Biomarker Information for Prediction of Survival of Non-Small-Cell Lung Cancer Patients Treated With Combined Chemotherapy and Radiation or Radiotherapy Alone (NCT00181519, NCT00573040, and NCT00572325). International Journal of Radiation Oncology Biology Physics, 81(2), 360-368. https://doi.org/10.1016/j.ijrobp.2010.06.011
  247. Quero, L., Dubois, L., Lieuwes, N. G., Hennequin, C., & Lambin, P. (2011). miR-210 as a marker of chronic hypoxia, but not a therapeutic target in prostate cancer. Radiotherapy and Oncology, 101(1), 203-208. https://doi.org/10.1016/j.radonc.2011.05.063
  248. Dubois, L. J., Lieuwes, N. G., Janssen, M. H. M., Peeters, W. J. M., Windhorst, A. D., Walsh, J. C., … Lambin, P. (2011). Preclinical evaluation and validation of [F-18]HX4, a promising hypoxia marker for PET imaging. Proceedings of the National Academy of Sciences of the United States of America, 108(35), 14620-14625. https://doi.org/10.1073/pnas.1102526108
  249. Ramaekers, B. L. T., Joore, M. A., Grutters, J. P. C., van den Ende, P., de Jong, J., Houben, R., … Langendijk, J. A. (2011). The impact of late treatment-toxicity on generic health-related quality of life in head and neck cancer patients after radiotherapy. Oral Oncology, 47(8), 768-774. https://doi.org/10.1016/j.oraloncology.2011.05.012
  250. van Loon, J., van Baardwijk, A., Boersma, L., Ollers, M., Lambin, P., & De Ruysscher, D. (2011). Therapeutic implications of molecular imaging with PET in the combined modality treatment of lung cancer. Cancer Treatment Reviews, 37(5), 331-343. https://doi.org/10.1016/j.ctrv.2011.01.005
  251. Egelmeer, A. G. T. M., Velazquez, E. R., de Jong, J. M. A., Oberije, C., Geussens, Y., Nuyts, S., … Lambin, P. (2011). Development and validation of a nomogram for prediction of survival and local control in laryngeal carcinoma patients treated with radiotherapy alone: A cohort study based on 994 patients. Radiotherapy and Oncology, 100(1), 108-115. https://doi.org/10.1016/j.radonc.2011.06.023
  252. Theys, J., Jutten, B., Habets, R., Paesmans, K., Groot, A. J., Lambin, P., … Vooijs, M. (2011). E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells. Radiotherapy and Oncology, 99(3), 392-397. https://doi.org/10.1016/j.radonc.2011.05.044
  253. Dubois, L., Peeters, S., Lieuwes, N. G., Geusens, N., Thiry, A., Wigfield, S., … Lambin, P. (2011). Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation. Radiotherapy and Oncology, 99(3), 424-431. https://doi.org/10.1016/j.radonc.2011.05.045
  254. van den Beucken, T., Magagnin, M. G., Jutten, B., Seigneuric, R., Lambin, P., Koritzinsky, M., & Wouters, B. G. (2011). Translational control is a major contributor to hypoxia induced gene expression. Radiotherapy and Oncology, 99(3), 379-384. https://doi.org/10.1016/j.radonc.2011.05.058
  255. van Loon, J., Offermann, C., Ollers, M., van Elmpt, W., Vegt, E., Rahmy, A., … De Ruysscher, D. (2011). Early CT and FDG-metabolic tumour volume changes show a significant correlation with survival in stage I-III small cell lung cancer: A hypothesis generating study. Radiotherapy and Oncology, 99(2), 172-175. https://doi.org/10.1016/j.radonc.2011.03.014
  256. van Elmpt, W., Hamill, J., Jones, J., De Ruysscher, D., Lambin, P., & Ollers, M. (2011). Optimal gating compared to 3D and 4D PET reconstruction for characterization of lung tumours. European Journal of Nuclear Medicine and Molecular Imaging, 38(5), 843-855. https://doi.org/10.1007/s00259-010-1716-6
  257. van den Bogaard, J., Janssen, M. H. M., Janssens, G. O., Buijsen, J., Reniers, B., Lambin, P., … Ollers, M. C. (2011). Residual metabolic tumor activity after chemo-radiotherapy is mainly located in initially high FDG uptake areas in rectal cancer. Radiotherapy and Oncology, 99(2), 137-141. https://doi.org/10.1016/j.radonc.2011.04.004
  258. Ramaekers, B. L. T., Pijls-Johannesma, M., Joore, M. A., van den Ende, P., Langendijk, J. A., Lambin, P., … Grutters, J. P. C. (2011). Systematic review and meta-analysis of radiotherapy in various head and neck cancers: Comparing photons, carbon-ions and protons. Cancer Treatment Reviews, 37(3), 185-201. https://doi.org/10.1016/j.ctrv.2010.08.004
  259. Buijsen, J., van den Bogaard, J., Janssen, M. H., Bakers, F. C., Engelsman, S., Ollers, M., … Lammering, G. (2011). FDG-PET provides the best correlation with the tumor specimen compared to MRI and CT in rectal cancer. Radiotherapy and Oncology, 98(2), 270-276. https://doi.org/10.1016/j.radonc.2010.11.018
  260. van Elmpt, W., Ollers, M., van Herwijnen, H., den Holder, L., Vercoulen, L., Wouters, M., … De Ruysscher, D. (2011). VOLUME OR POSITION CHANGES OF PRIMARY LUNG TUMOR DURING (CHEMO-)RADIOTHERAPY CANNOT BE USED AS A SURROGATE FOR MEDIASTINAL LYMPH NODE CHANGES: THE CASE FOR OPTIMAL MEDIASTINAL LYMPH NODE IMAGING DURING RADIOTHERAPY. International Journal of Radiation Oncology Biology Physics, 79(1), 89-95. https://doi.org/10.1016/j.ijrobp.2009.10.059
  261. van Stiphout, R. G. P. M., Lammering, G., Buijsen, J., Janssen, M. N. M., Gambacorta, M. A., Slagmolen, P., … Lambin, P. (2011). Development and external validation of a predictive model for pathological complete response of rectal cancer patients including sequential PET-CT imaging. Radiotherapy and Oncology, 98(1), 126-133. https://doi.org/10.1016/j.radonc.2010.12.002
  262. 2010
  263. Roelofs, E., Persoon, L., Qamhiyeh, S., Verhaegen, F., De Ruysscher, D., Scholz, M., … Lambin, P. (2010). Design of and technical challenges involved in a framework for multicentric radiotherapy treatment planning studies. Radiotherapy and Oncology, 97(3), 567-571. https://doi.org/10.1016/j.radonc.2010.08.009
  264. Dehing-Oberije, C., De Ruysscher, D., Petit, S., Van Meerbeeck, J., Vandecasteele, K., De Neve, W., … Lambin, P. (2010). Development, external validation and clinical usefulness of a practical prediction model for radiation-induced dysphagia in lung cancer patients. Radiotherapy and Oncology, 97(3), 455-461. https://doi.org/10.1016/j.radonc.2010.09.028
  265. Jimenez, M. F., van Baardwijk, A., Aerts, H. J. W. L., De Ruysscher, D., Novoa, N. M., Varela, G., & Lambin, P. (2010). Effectiveness of surgery and individualized high-dose hyperfractionated accelerated radiotherapy on survival in clinical stage I non-small cell lung cancer. A propensity score matched analysis. Radiotherapy and Oncology, 97(3), 413-417. https://doi.org/10.1016/j.radonc.2010.08.016
  266. Grutters, J. P. C., Joore, M. A., Wiegman, E. M., Langendijk, J. A., de Ruysscher, D., Hochstenbag, M., … Pijls-Johannesma, M. (2010). Health-related quality of life in patients surviving non-small cell lung cancer. Thorax, 65(10), 903-907. https://doi.org/10.1136/thx.2010.136390
  267. Velazquez, E. R., Aerts, H. J. W. L., Oberije, C., De Ruysscher, D., & Lambin, P. (2010). Prediction of residual metabolic activity after treatment in NSCLC patients. Acta Oncologica, 49(7), 1033-1039. https://doi.org/10.3109/0284186X.2010.498441
  268. Grutters, J. P. C., Pijls-Johannesma, M., De Ruysscher, D., Peeters, A., Reimoser, S., Severens, J. L., … Joore, M. A. (2010). The cost-effectiveness of particle therapy in non-small cell lung cancer: Exploring decision uncertainty and areas for future research. Cancer Treatment Reviews, 36(6), 468-476. https://doi.org/10.1016/j.ctrv.2010.02.018
  269. Lammering, G., De Ruysscher, D., van Baardwijk, A., Baumert, B. G., Borger, J., Lutgens, L., … Lambin, P. (2010). The Use of FDG-PET to Target Tumors by Radiotherapy. Strahlentherapie Und onkologie, 186(9), 471-481. https://doi.org/10.1007/s00066-010-2150-1
  270. van Loon, J., Janssen, M. H. M., Ollers, M., Aerts, H. J. W. L., Dubois, L., Hochstenbag, M., … Lambin, P. (2010). PET imaging of hypoxia using [F-18]HX4: a phase I trial. European Journal of Nuclear Medicine and Molecular Imaging, 37(9), 1663-1668. https://doi.org/10.1007/s00259-010-1437-x
  271. Lambin, P., Petit, S. F., Aerts, H. J. W. L., van Elmpt, W. J. C., Oberije, C. J. G., Starmans, M. H. W., … De Ruysscher, D. (2010). The ESTRO Breur Lecture 2009. From population to voxel-based radiotherapy: Exploiting intra-tumour and intra-organ heterogeneity for advanced treatment of non-small cell lung cancer. Radiotherapy and Oncology, 96(2), 145-152. https://doi.org/10.1016/j.radonc.2010.07.001
  272. Akurathi, V., Dubois, L., Lieuwes, N. G., Chitneni, S. K., Cleynhens, B. J., Vullo, D., … Bormans, G. M. (2010). Synthesis and biological evaluation of a Tc-99m-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia. Nuclear Medicine and Biology, 37(5), 557-564. https://doi.org/10.1016/j.nucmedbio.2010.02.006
  273. Janssen, M. H. M., Öllers, M. C., Riedl, R. G., van den Bogaard, J., Buijsen, J., van Stiphout, R. G. P. M., … Lammering, G. (2010). Accurate Prediction of Pathological Rectal Tumor Response after Two Weeks of Preoperative Radiochemotherapy Using 18F-Fluorodeoxyglucose-Positron Emission Tomography-Computed Tomography Imaging. International Journal of Radiation Oncology Biology Physics, 77(2), 392-399. https://doi.org/10.1016/j.ijrobp.2009.04.030
  274. Kierkels, R. G. J., Backes, W. H., Janssen, M. H. M., Buijsen, J., Beets-Tan, R. G. H., Lambin, P., … Aerts, H. J. W. L. (2010). COMPARISON BETWEEN PERFUSION COMPUTED TOMOGRAPHY AND DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING IN RECTAL CANCER. International Journal of Radiation Oncology Biology Physics, 77(2), 400-408. https://doi.org/10.1016/j.ijrobp.2009.05.015
  275. van Loon, J., De Ruysscher, D., Wanders, R., Boersma, L., Simons, J. P., Oellers, M., … Lambin, P. (2010). Selective nodal irradiation on basis of (18)FDG-PET scans in limited-disease small-cell lung cancer: a prospective study. International Journal of Radiation Oncology Biology Physics, 77(2), 329-36. https://doi.org/10.1016/j.ijrobp.2009.04.075
  276. Hatt, M., le Rest, C. C., Descourt, P., Dekker, A., De Ruysscher, D., Oellers, M., … Visvikis, D. (2010). ACCURATE AUTOMATIC DELINEATION OF HETEROGENEOUS FUNCTIONAL VOLUMES IN POSITRON EMISSION TOMOGRAPHY FOR ONCOLOGY APPLICATIONS. International Journal of Radiation Oncology Biology Physics, 77(1), 301-308. https://doi.org/10.1016/j.ijrobp.2009.08.018
  277. Pijls-Johannesma, M., van Mastrigt, G., Hahn, S. M., De Ruysscher, D., Baumert, B. G., Lammering, G., … Lambin, P. (2010). A systematic methodology review of phase I radiation dose escalation trials. Radiotherapy and Oncology, 95(2), 135-141. https://doi.org/10.1016/j.radonc.2010.02.009
  278. Janssen, M. H. M., Ollers, M. C., van Stiphout, R. G. P. M., Riedl, R. G., van den Bogaard, J., Buijsen, J., … Lammering, G. (2010). Blood glucose level normalization and accurate timing improves the accuracy of PET-based treatment response predictions in rectal cancer. Radiotherapy and Oncology, 95(2), 203-208. https://doi.org/10.1016/j.radonc.2010.01.021
  279. Kimman, M. L., Bloebaum, M. M. F., Dirksen, C. D., Houben, R. M. A., Lambin, P., & Boersma, L. J. (2010). Patient satisfaction with nurse-led telephone follow-up after curative treatment for breast cancer. BMC Cancer, 10, 174. https://doi.org/10.1186/1471-2407-10-174
  280. Jayasurya, K., Fung, G., Yu, S., Dehing-Oberije, C., De Ruysscher, D., Hope, G. A., … Dekker, A. L. A. J. (2010). Comparison of Bayesian network and support vector machine models for two-year survival prediction in lung cancer patients treated with radiotherapy. Medical Physics, 37(4), 1401-1407. https://doi.org/10.1118/1.3352709
  281. Grutters, J. P. C., Kessels, A. G. H., Pijls-Johannesma, M., De Ruysscher, D., Joore, M. A., & Lambin, P. (2010). Comparison of the effectiveness of radiotherapy with photons, protons and carbon-ions for non-small cell lung cancer: A meta-analysis. Radiotherapy and Oncology, 95(1), 32-40. https://doi.org/10.1016/j.radonc.2009.08.003
  282. Peeters, A., Grutters, J. P. C., Pijls-Johannesma, M., Reimoser, S., De Ruysscher, D., Severens, J. L., … Lambin, P. (2010). How costly is particle therapy? Cost analysis of external beam radiotherapy with carbon-ions, protons and photons. Radiotherapy and Oncology, 95(1), 45-53. https://doi.org/10.1016/j.radonc.2009.12.002
  283. van Baardwijk, A., Wanders, S., Boersma, L., Borger, J., Oellers, M., Dingemans, A-M. C., … De Ruysscher, D. (2010). Mature Results of an Individualized Radiation Dose Prescription Study Based on Normal Tissue Constraints in Stages I to III Non-Small-Cell Lung Cancer. Journal of Clinical Oncology, 28(8), 1380-1386. https://doi.org/10.1200/JCO.2009.24.7221
  284. Petit, S. F., van Elmpt, W. J. C., Lambin, P., & Dekker, A. L. A. J. (2010). Dose recalculation in megavoltage cone-beam CT for treatment evaluation: Removal of cupping and truncation artefacts in scans of the thorax and abdomen. Radiotherapy and Oncology, 94(3), 359-366. https://doi.org/10.1016/j.radonc.2009.12.001
  285. van Elmpt, W., Petit, S., De Ruysscher, D., Lambin, P., & Dekker, A. (2010). 3D dose delivery verification using repeated cone-beam imaging and EPID dosimetry for stereotactic body radiotherapy of non-small cell lung cancer. Radiotherapy and Oncology, 94(2), 188-194. https://doi.org/10.1016/j.radonc.2009.12.024
  286. Janssen, M. H. M., Ollers, M. C., van Stiphout, R. G. P. M., Buijsen, J., van den Bogaard, J., de Ruysscher, D., … Lammering, G. (2010). Evaluation of early metabolic responses in rectal cancer during combined radiochemotherapy or radiotherapy alone: Sequential FDG-PET-CT findings. Radiotherapy and Oncology, 94(2), 151-155. https://doi.org/10.1016/j.radonc.2009.12.033
  287. Janssen, M. H. M., Aerts, H. J. W. L., Kierkels, R. G. J., Backes, W. H., Ollers, M. C., Buijsen, J., … Lammering, G. (2010). Tumor perfusion increases during hypofractionated short-course radiotherapy in rectal cancer: Sequential perfusion-CT findings. Radiotherapy and Oncology, 94(2), 156-160. https://doi.org/10.1016/j.radonc.2009.12.013
  288. Grutters, J., Abrams, K. R., Pijls – Johannesma, M. C. G., de Ruysscher, D. K. M., Peters, H. J. M., Beutner, E. A., … Joore, M. A. (2010). Deciding upon New and Expensive Technologies in Cancer Care: Real Options Analysis in Proton Therapy. Maastricht: Mimeo, CAPHRI School for Public Health and Primary Care.
  289. Jager, J. J., Keymeulen, K. B. I. M., Beets Tan, R. G., Hupperets, P., van Kroonenburgh, M., Houben, R., … Boersma, L. J. (2010). FDG-PET-CT for staging of high-risk breast cancer patients reduces the number of further examinations: A pilot study. Acta Oncologica, 49(2), 185-91. https://doi.org/10.3109/02841860903440262
  290. van Loon, J., Grutters, J. P. C., Wanders, R., Boersma, L., Dingemans, A-M. C., Bootsma, G., … De Ruysscher, D. (2010). (18)FDG-PET-CT in the follow-up of non-small cell lung cancer patients after radical radiotherapy with or without chemotherapy: An economic evaluation. European Journal of Cancer, 46(1), 110-119. https://doi.org/10.1016/j.ejca.2009.10.028
  291. Rouschop, K. M. A., van den Beucken, T., Dubois, L., Niessen, H., Bussink, J., Savelkouls, K., … Wouters, B. G. (2010). The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. Journal of Clinical Investigation, 120(1), 127-141. https://doi.org/10.1172/JCI40027
  292. Rami, M., Montero, J-L., Dubois, L., Lambin, P., Scozzafava, A., Winum, J-Y., & Supuran, C. T. (2010). Carbonic anhydrase inhibitors: Gd(III) complexes of DOTA- and TETA-sulfonamide conjugates targeting the tumor associated carbonic anhydrase isozymes IX and XII. New Journal of Chemistry, 34(10), 2139-2144. https://doi.org/10.1039/c0nj00214c
  293. Lutgens, L., van der Zee, J., Pijls-Johannesma, M., De Haas-Kock, D. F. M., Buijsen, J., Mastrigt, G. A. P. G. . V., … Lambin, P. (2010). Combined use of hyperthermia and radiation therapy for treating locally advanced cervical carcinoma (Withdrawn Paper, art. no. CD006377, 2010). Cochrane Database of Systematic Reviews, (1), [CD006377]. https://doi.org/10.1002/14651858.CD006377.pub2
  294. Pijls-Johannesma, M., Grutters, J. P. C., Verhaegen, F., Lambin, P., & De Ruysscher, D. (2010). Do We Have Enough Evidence to Implement Particle Therapy as Standard Treatment in Lung Cancer? A Systematic Literature Review. Oncologist, 15(1), 93-103. https://doi.org/10.1634/theoncologist.2009-0116
  295. Kimman, M. L., Dellaert, B. G. C., Boersma, L. J., Lambin, P., & Dirksen, C. D. (2010). Follow-up after treatment for breast cancer: One strategy fits all? An investigation of patient preferences using a discrete choice experiment. Acta Oncologica, 49(3), 328-337. https://doi.org/10.3109/02841860903536002
  296. 2009
  297. Theys, J., Jutten, B., Dubois, L. J., Rouschop, K. M. A., Chiu, R. K., Li, Y., … Wouters, B. G. (2009). The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment. Radiotherapy and Oncology, 92(3), 399-404. https://doi.org/10.1016/j.radonc.2009.06.017
  298. 2007
  299. Kimman, M. L., Voogd, A. C., Dirksen, C. D., Falger, P. R. J., Hupperets, P. S. G. J., Keymeulen, K. B. I. M., … Boersma, L. J. (2007). Follow-up after curative treatment for breast cancer: why do we still adhere to frequent outpatient clinic visits? European Journal of Cancer, 43(4), 647-653. https://doi.org/10.1016/j.ejca.2006.12.002
  300. Langie, S. A., Knaapen, A. M., Ramaekers, C. H. M. A., Theys, J., Brun, J., Godschalk, R. W., … Chiu, R. K. (2007). Formation of lysine 63-linked poly-ubiquitin chains protects human lung cells against benzo[a]pyrene-diol-epoxide-induced mutagenicity. Dna Repair, 6(6), 852-862. https://doi.org/10.1016/j.dnarep.2007.02.012
  301. Dagnelie, P., Pijls-Johannesma, M. C. G., Lambin, P., Beijer, S., De Ruysscher, D., & Kempen, G. I. J. M. (2007). Impact of fatigue on overall quality of life in lung and breast cancer patients selected for high-dose radiotherapy. Annals of Oncology, 18(5), 940-944. https://doi.org/10.1093/annonc/mdm057
  302. Seigneuric, R., Starmans, M. H. W., Fung, G., Krishnapuram, B., Nuyten, D. S. A., van Erk, A. A., … Lambin, P. (2007). Impact of supervised gene signatures of early hypoxia on patient survival. Radiotherapy and Oncology, 83(3), 374-382. https://doi.org/10.1016/j.radonc.2007.05.002
  303. Kimman, M. L., Voogd, A. C., Dirksen, C. D., Falger, P. R. J., Hupperets, P. S. G. J., Keymeulen, K. B. I. M., … Boersma, L. J. (2007). Improving the quality and efficiency of follow-up after curative treatment for breast cancer–rationale and study design of the MaCare trial. BMC Cancer, 7, 1. https://doi.org/10.1186/1471-2407-7-1
  304. 2006
  305. Dagnelie, P. C., Pijls-Johannesma, M. C. G., Pijpe, A., Boumans, B. J., Skrabanja, A. T., Lambin, P., & Kempen, G. I. J. M. (2006). Psychometric properties of the revised Piper Fatigue Scale in Dutch cancer patients were satisfactory. Journal of Clinical Epidemiology, 59(6), 642-649. https://doi.org/10.1016/j.jclinepi.2005.09.015
  306. 2005
  307. de Lussanet, Q. G., Backes, W. H., Griffioen, A. W., Padhani, A. R., Baeten, C. G., van Baardwijk, A. A. W., … Beets-Tan, R. G. H. (2005). Dynamic contrast-enhanced magnetic resonance imaging of radiation therapy-induced microcirculation changes in rectal cancer. International Journal of Radiation Oncology Biology Physics, 63(3), 1309-1315. https://doi.org/10.1016/j.ijrobp.2005.04.052
  308. Pijls-Johannesma, M. C. G., Pijpe, A., Kempen, G. I. J. M., Lambin, P., & Dagnelie, P. C. (2005). Health related quality of life assessment instruments: a prospective study on preference and acceptability among cancer patients referred for radiotherapy. European Journal of Cancer, 41(15), 2250-2256. https://doi.org/10.1016/j.ejca.2005.06.019
  309. Lutgens, L. C. H. W., Blijlevens, N. M., Deutz, N. E., Donnelly, J. P., Lambin, P., & de Pauw, B. E. (2005). Monitoring myeloablative therapy-induced small bowel toxicity by serum citrulline concentration: a comparison with sugar permeability tests. Cancer, 103(1), 191-199. https://doi.org/10.1002/cncr.20733
  310. 2004
  311. Lutgens, L. C. H. W., Deutz, N., Granzier-Peeters, M., Beets-Tan, R. G. H., de Ruysscher, D. K. M., Gueulette, J., … Lambin, P. (2004). Plasma citrulline concentration: a surrogate end point for radiation-induced mucosal atrophy of the small bowel. A feasibility study in 23 patients. International Journal of Radiation Oncology Biology Physics, 60(1), 275-85. https://doi.org/10.1016/j.ijrobp.2004.02.052
  312. 2003
  313. Lutgens, L. C. H. W., Deutz, N. E. P., Gueulette, J., Cleutjens, J. P. M., Berger, M. P. F., Wouters, B. G., … Lambin, P. (2003). Citrulline: a physiologic marker enabling quantitation and monitoring of epithelial radiation-induced small bowel damage. International Journal of Radiation Oncology Biology Physics, 57(4), 1067-1074. https://doi.org/10.1016/S0360-3016(03)00781-8
  314. 2001
  315. Lambin, P. (2001). Oxygen and cancer: friends or enemies? Maastricht: Maastricht University. https://doi.org/10.26481/spe.20010914pl